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anaxirone

Product Name
anaxirone
CAS No.
77658-97-0
Chemical Name
anaxirone
Synonyms
anaxirone;NSC-332488;Triglycidylurazole;1,2,4-triglycidyl urazol;1,2,4-Triazolidine-3,5-dione,1,2,4-tris(2-oxiranylmethyl)-;1,2,4-Tris(oxiran-2-ylmethyl)-1,2,4-triazolidine-3,5-dione
CBNumber
CB8891567
Molecular Formula
C11H15N3O5
Formula Weight
269.25
MOL File
77658-97-0.mol
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anaxirone Property

Melting point:
91°C
Boiling point:
412.4°C (rough estimate)
Density 
1.2986 (rough estimate)
refractive index 
1.4930 (estimate)
pka
-1.72±0.20(Predicted)
Water Solubility 
0.2g/L(temperature not stated)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0010709
Product name
ANAXIRONE
Purity
95.00%
Packaging
5MG
Price
$504.54
Updated
2021/12/16
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anaxirone Chemical Properties,Usage,Production

Originator

Anaxirone, Onbio Inc.

Uses

Triglycidylurazole is a drug shown to reduce tumor-induced bone destruction in the rat.

Manufacturing Process

In a 4-liter three-necked flask equipped with a stirrer, thermometer and reflux condenser, 101 g (1 mole) of triazolidine-3,5-dione, 2775 g (30 moles) of epichlorohydrin and 2 ml of triethylamine are heated to 80°C by means of an oil bath. The mixture reacts exothermically so that the oil bath may be removed. After the exothermic reaction has abated, the reaction mixture is stirred at 80°C. The total reaction time is 10 hours. 250 g of 50% sodium hydroxide solution are added dropwise to the solution obtained over a period of 4 hours at from 30 to 40°C in such a way that the water added and the water formed during the reaction is continuously removed by azeotropic distillation at from 30 to 60 Torr using a water separator. To complete the reaction, the reaction mixture is stirred for another hour and the sodium chloride formed is separated by filtration. The sodium chloride is washed twice with 200 g of epichlorohydrin and the combined epichlorohydrin solutions are washed with 200 ml of water. After the organic phase has been dried over sodium sulfate, the solvent is removed by concentration in a rotary evaporator and the residue is dried, ultimately at 80°C/0.2 mbar, to constant weight. 240 g of a light brown viscous oil are obtained. It was found to have an epoxide value of 0.93 and has a chlorine content of 2.75%. The viscous oil crystallizes after standing for from a few hours to days. The practically pure 1,2,4- triglycidyl triazolidine-3,5-dione melting at from 98° to 103°C crystallizes by dissolution in methanol and cooling to 5°C. IR- and NMR-spectra in conjunction with elemental analysis and epoxide determination confirm the assumed structure. Melting point 94-96°C.

Therapeutic Function

Antineoplastic

anaxirone Preparation Products And Raw materials

Raw materials

Preparation Products

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anaxirone Suppliers

Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18478
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19711
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
Tel
027-88013699 17354350817
Email
Ryan@jiutian-bio.com
Country
China
ProdList
6001
Advantage
58

77658-97-0, anaxironeRelated Search:


  • anaxirone
  • 1,2,4-triglycidyl urazol
  • 1,2,4-Tris(oxiran-2-ylmethyl)-1,2,4-triazolidine-3,5-dione
  • NSC-332488
  • Triglycidylurazole
  • 1,2,4-Triazolidine-3,5-dione,1,2,4-tris(2-oxiranylmethyl)-
  • 77658-97-0