(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

ChemicalBook > CAS DataBase List > (±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

Product Name: (±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
CAS No.: 38396-39-3
Chemical Name: (±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
Synonyms: Bupivacaina;Ah 250;Bucain;Bupivan;Rac-Bupivacaine;Bupivacaine Free Base;Bupivacaine (SKY 0402);Bupivacaine Base (IHS);(R,S)-Bupivqacaine hydrochloride;BUPIVACAINE FREE BASEBUPIVACAINE FREE BASE
CBNumber: CB8897837
Molecular Formula: C18H28N2O
Formula Weight: 288.43
MOL File: 38396-39-3.mol

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(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Property

Melting point:: 106-110℃
Boiling point:: 423.4±45.0 °C(Predicted)
Density: 1.032±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:25.0(Max Conc. mg/mL);86.68(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);104.01(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);104.01(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.73(Max Conc. mM)
form: Cyrstalline powder
pka: 14.85±0.70(Predicted)
color: White to off-white
Water Solubility: Soluble in water, ethanol, chloroform (slightly ), and acetone (slightly ).
EPA Substance Registry System: 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)- (38396-39-3)

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Safety

TSCA: Yes
HazardClass: 6.1
Hazardous Substances Data: 38396-39-3(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

Precautionary statements

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P320Specific treatment is urgent (see … on this label).

P330Rinse mouth.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J62742
Product name: Bupivacaine
Packaging: 1g
Price: $155.65
Updated: 2024/03/01

Alfa Aesar

Product number: J62742
Product name: Bupivacaine
Packaging: 5g
Price: $262.65
Updated: 2024/03/01

Cayman Chemical

Product number: 16618
Product name: Bupivacaine
Purity: ≥98%
Packaging: 1g
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 16618
Product name: Bupivacaine
Purity: ≥98%
Packaging: 5g
Price: $68
Updated: 2024/03/01

Alfa Aesar

Product number: J62742
Product name: Bupivacaine
Packaging: 25g
Price: $1158
Updated: 2024/03/01

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(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical Properties,Usage,Production

Description

Bupivacaine is a sodium channel blocker and local anesthetic. It inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner and inhibits synaptic transmission in rat sympathetic ganglia, increasing the firing threshold when used at a concentration of 200 nM. Bupivacaine (10 μM) blocks cardiac sodium channels in a use-dependent manner and inhibits respiration in cardiac cell mitochondria when palmitoyl-carnitine or acetyl-carnitine are used as substrates (IC₅₀s = 0.78 and 0.37 mM, respectively). It also reduces thermal hyperplasia in a rat model of sciatic ligation injury when 0.6 ml of a 0.5% solution is administered into the perinerve space, and the duration of this effect is extended by co-administration of the NMDA receptor antagonist MK-801 . Formulations containing bupivacaine have been used as local anesthetics for surgery, oral surgery, and dental procedures and for anesthetic purposes in research studies using animals.

Uses

Bupivacaine acts as a potent and long-acting local anesthetic agent in vivo. At 100 μM, it has been reported to inhibit the uptake of dopamine in striatal synaptosomes by 47%.

Definition

ChEBI: A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.

(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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38396-39-3, (±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Related Search:

Bupivacaine Hydrochloride 2,6-PIPECOLINOXYLIDIDE HYDROCHLORIDE BUPIVACAINE N-OXIDE Levobupivacaine hydrochloride Bupivacaine Impurity Bupivacaine Impurity N-(3,5-dimethylphenyl)picolinamide Levobupivacaine hydrochloride Bupivacaine IMpurity A Bupivacaine hydrochloride (R)-(+)-BUPIVACAINE HCL Bupivacaine IMpurity F Bupivacaine-d9 Bupivacaine Impurity Bupivacaine EP Impurity C Bupivacaine-(butyl-1-13C) Bupivacaine IMpurity C Bupivacaine hydrochloride monohydrate

1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboximidic Acid

2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-

Bupivan

(R,S)-Bupivqacaine hydrochloride

rac-(2R*)-N-(2,6-Dimethylphenyl)-1-butyl-2β*-piperidinecarboxamide

(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

Ah 250

Bupivacaina

Bupivacaine Free Base

Bucain

BUPIVACAINE FREE BASEBUPIVACAINE FREE BASE

Rac-Bupivacaine

Bupivacaine (SKY 0402)

1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboximidicaci

Bupivacaine Base (IHS)

38396-39-3