ChemicalBook > CAS DataBase List > 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt

1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt

Product Name
1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt
CAS No.
17795-21-0
Chemical Name
1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt
Synonyms
Aloprim;Allopurinolsodium;Sodium allopurinol;Allopurinol sodium salt;LOPURIN;ZYLOPRIM;ALOPRIM;Allopurinol SodiuM (AlopriM);Allopurinol Sodium, 10 mM in DMSO;SodiuM 1H-pyrazolo[3,4-d]pyriMidin-4-olate;1H-Pyrazolo[3,4-d]pyrimidin-4-ol monosodium salt;1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,monosodiumsal
CBNumber
CB8909257
Molecular Formula
C5H5N4NaO
Formula Weight
160.11
MOL File
17795-21-0.mol
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1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt Property

storage temp. 
Sealed in dry,Room Temperature
pka
9.31(at 25℃)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Matrix Scientific
Product number
091150
Product name
Sodium 1H-pyrazolo[3,4-d]pyrimidin-4-olate
Purity
95+%
Packaging
1g
Price
$227
Updated
2021/12/16
ApexBio Technology
Product number
B2074
Product name
AllopurinolSodium
Packaging
25g
Price
$106
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000940
Product name
SODIUM ALLOPURINOL
Purity
95.00%
Packaging
1G
Price
$284.55
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134402
Product name
Allopurinol Sodium (Aloprim)
Purity
>99%
Packaging
100mg
Price
$510
Updated
2021/12/16
Matrix Scientific
Product number
091150
Product name
Sodium 1H-pyrazolo[3,4-d]pyrimidin-4-olate
Purity
95+%
Packaging
5g
Price
$605
Updated
2021/12/16
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1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt Chemical Properties,Usage,Production

Uses

Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect[1][2][3][4][5].

in vivo

Allopurinol sodium (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse[3].
Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse[4].

Animal Model:20-30 g, male Swiss Albino mice[3]
Dosage:39 mg/kg
Administration:P.o.; daily for 21 successive days
Result:Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s.
Animal Model:30-40 g, male adult Swiss albino mice[4]
Dosage:10, 50, 100, 200, 400 mg/kg
Administration:I.p.
Result:Produced dose-dependent anti-nociception in the tail-flick, hot-plate.

References

[1] Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006;58(1):87-114. DOI:10.1124/pr.58.1.6
[2] Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472. DOI:10.1128/AAC.5.5.469
[3] Karve AV, et al. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45(3):244-7. DOI:10.4103/0253-7613.111922
[4] Schmidt AP, et al. Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. Br J Pharmacol. 2009 Jan;156(1):163-72. DOI:10.1111/j.1476-5381.2008.00025.x
[5] Sun Y, et al. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS One. 2015 Apr 1;10(4):e0123649. DOI:10.1371/journal.pone.0123649

1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt Suppliers

China 52 Germany 1 India 2 United States 17 Global 72
JinYan Chemicals(ShangHai) Co.,Ltd.
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orders@biochemsafebuy.com
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View Lastest Price from 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt manufacturers

Dideu Industries Group Limited
Product
1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt 17795-21-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons
Release date
2022-02-16

17795-21-0, 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium saltRelated Search:

2'-Deoxyadenosine Bithionol Octamethylcyclotetrasiloxane Allopurinol

  • 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt
  • Allopurinolsodium
  • 1H-Pyrazolo[3,4-d]pyrimidin-4-ol monosodium salt
  • Sodium allopurinol
  • Allopurinol SodiuM (AlopriM)
  • SodiuM 1H-pyrazolo[3,4-d]pyriMidin-4-olate
  • Aloprim
  • 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, sodium salt (1:1)
  • LOPURIN;ZYLOPRIM;ALOPRIM
  • Allopurinol sodium salt
  • 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one,monosodiumsal
  • 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt ISO 9001：2015 REACH
  • anti-nociception,HIF-2α,inhibit,anti-leishmanial,gout,hyperuricemia,HIF-1α,HUVEC cells,anti-depressant,Allopurinol,Inhibitor,Allopurinol Sodium,orally active,Xanthine Oxidase
  • Allopurinol Sodium, 10 mM in DMSO
  • 17795-21-0
  • C5H3N4NaO
  • Inhibitors