methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate

Product Name: methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
CAS No.: 1601-18-9
Chemical Name: methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
Synonyms: L 588983;Indometacin Impurity H;Indapamide EP Impurity H;Indomethacin Methyl Ester;Indometacin EP Impurity H;Indomethacin EP Impurity H;Methyl 2-(1-(4-chlorobenzoyl);Methyl [1-(4-Chlorobenzoyl)-5-metho;Indomethacin Impurity 8(Indomethacin EP Impurity H);Methyl N-(p-Chlorobenzoyl)-2-Methyl-5-Methoxy-3-indolylacetate
CBNumber: CB8912958
Molecular Formula: C20H18ClNO4
Formula Weight: 371.81
MOL File: 1601-18-9.mol

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methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate Property

Melting point:: 99-100 °C
Boiling point:: 463.4±45.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
form: Solid
color: Pale Yellow to Light Green
NIST Chemistry Reference: Indomethacin, methyl ester(1601-18-9)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: I641025
Product name: IndomethacinMethylEster
Packaging: 5mg
Price: $65
Updated: 2021/12/16

Usbiological

Product number: 280435
Product name: Indomethacin methyl ester
Packaging: 5mg
Price: $403
Updated: 2021/12/16

AK Scientific

Product number: 2702AQ
Product name: METHYL1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETATE
Packaging: 1g
Price: $372.8
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0173717
Product name: METHYL 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETATE
Purity: 95.00%
Packaging: 5MG
Price: $505.75
Updated: 2021/12/16

Ambeed

Product number: A706743
Product name: Methyl2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate
Purity: 98%
Packaging: 100mg
Price: $52
Updated: 2021/12/16

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methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate Chemical Properties,Usage,Production

Chemical Properties

Pale Green Solid

Uses

Selective COX-2 inhibitor

Synthesis

67-56-1

53-86-1

1601-18-9

GENERAL METHOD: 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid (1 eq.) and BOP-Cl (1 eq.) were suspended in dichloromethane (20 mL/g of acid), triethylamine (2 eq.) was added slowly and the mixture was stirred for 10 minutes. Methanol (4 eq.) was then added and the reaction mixture continued to be stirred for at least 12 hours. Upon completion of the reaction, the solvent was removed by evaporation and the resulting solid was purified by column chromatography with the eluent being a solvent mixture of hexane and ethyl acetate (3:1, v/v) at a boiling range of 80-100°C. Finally, the solvent was removed under reduced pressure to give methyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate as a light yellow solid.

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 15, p. 4830 - 4837
[2] Pharmazie, 2003, vol. 58, # 2, p. 99 - 103
[3] Patent: CN105418480, 2016, A. Location in patent: Paragraph 0031
[4] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 3, p. 745 - 762
[5] European Journal of Pharmaceutical Sciences, 2001, vol. 14, # 4, p. 301 - 311

methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate manufacturers

Career Henan Chemica Co

Product: methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate 1601-18-9
Price: US $0.01/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1kg; 5kg; 10kg
Release date: 2020-10-27

1601-18-9, methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetateRelated Search:

Methanone, (4-chlorophenyl)[2,6-dichloro-4-(hydroxymethyl)phenyl]- Indometacin Impurity 17 Indomethacin-d4 Indometacin 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, ethyl ester 4-Chloro-2-(4-chlorobenzoyl)-1-(4-Methoxyphenyl)hydrazide Benzoic Acid 4-Chloro-N-(4-Methoxyphenyl)benzaMide, 97% IndoMethacin DiaMide 2-(4-METHOXYPHENYL)HYDRAZINESULFONIC ACID SODIUM SALT MONOHYDRATE 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID 4-Chlorobenzoic acid Indometacin EP Impurity G 1H-INDOLE-3-ACETICACID,1-(3-CHLOROBENZOYL)-5-METHOXY-2-METHYL Indometacin Impurity 16 Benzoic acid, 4-chloro-, 2,3-dihydroxypropyl ester 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-hydroxypropyl ester 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-,2,3-d ihydroxypropyl ester Indometacin Impurity 18

methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate

[1-(4-Chlorobenzoyl)-2-methyl-5-methoxy-1H-indole-3-yl]acetic acid methyl ester

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid methyl ester

Indomethacin Methyl Ester

2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetic acid methyl ester

methyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate

methyl 2-[1-(4-chlorophenyl)carbonyl-5-methoxy-2-methyl-indol-3-yl]ethanoate

1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, Methyl ester

L 588983

Methyl N-(p-Chlorobenzoyl)-2-Methyl-5-Methoxy-3-indolylacetate

Methyl 2-(1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-1H-indol-3-yl)acetate

Methyl 2-(1-(4-chlorobenzoyl)

Indometacin EP Impurity H

Indomethacin Impurity 8(Indomethacin EP Impurity H)

Indomethacin impurity 7/Indomethacin EP Impurity H/methyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate

Indomethacin EP Impurity H

Indapamide EP Impurity H

Methyl [1-(4-Chlorobenzoyl)-5-metho

Methyl [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate

Indometacin Impurity H

Indomethacin (Indometacin) EP Impurity H (Indomethacin Methyl Ester)

Methyl 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl]acetate

Methyl [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate (Indomethacin Methyl Ester)

Indometacin Imp.H (EP): methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-ylacetate

1601-18-9

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