ethyl 2,2-dichloroacetoacetate
- Product Name
- ethyl 2,2-dichloroacetoacetate
- CAS No.
- 6134-66-3
- Chemical Name
- ethyl 2,2-dichloroacetoacetate
- Synonyms
- Einecs 228-104-3;Amlodipine Impurity 27;7-Naphthaleneethanamine;Indomethacin Impurity 30;ethyl 2,2-dichloroacetoacetate;Ethyl 2,2-dichloro-3-oxobutanoate;2,2-Dichloroacetoacetic acid ethyl ester;2,2-Dichloro-3-oxobutyric acid ethyl ester;2,2-Dichloro-3-oxobutanoic acid ethyl ester;Ethyl 2,2-dichloro-3-oxobutanoate - [E71803]
- CBNumber
- CB8916855
- Molecular Formula
- C6H8Cl2O3
- Formula Weight
- 199.03
- MOL File
- 6134-66-3.mol
ethyl 2,2-dichloroacetoacetate Property
- Boiling point:
- 285.68°C (rough estimate)
- Density
- 1.2920
- refractive index
- 1.4492 (estimate)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly)
- form
- liquid
- color
- Colourless to light yellow
Safety
- RIDADR
- 2920
- PackingGroup
- Ⅲ
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E903078
- Product name
- Ethyl2,2-Dichloro-3-oxobutanoate
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 6685AE
- Product name
- Ethyl2,2-dichloro-3-oxobutanoate
- Packaging
- 1g
- Price
- $192
- Updated
- 2021/12/16
- Product number
- 092508
- Product name
- Ethyl 2,2-dichloro-3-oxobutanoate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $416
- Updated
- 2021/12/16
- Product number
- CHM1049139
- Product name
- ETHYL 2,2-DICHLORO-3-OXOBUTANOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.41
- Updated
- 2021/12/16
- Product number
- 092508
- Product name
- Ethyl 2,2-dichloro-3-oxobutanoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $924
- Updated
- 2021/12/16
ethyl 2,2-dichloroacetoacetate Chemical Properties,Usage,Production
Uses
Ethyl 2,2-dichloroacetoacetate is an organic synthesis intermediate, mainly used in the synthesis of pesticides, medicines, dyes and other chemicals.
Synthesis
141-97-9
6134-66-3
The general procedure for the synthesis of ethyl 2,2-dichloro-3-oxobutanoate from ethyl acetoacetate was as follows: a mixture of 2.5 mmol NH4Cl, 5.0 mmol ethyl acetoacetate and 10.0 mL acetonitrile was stirred for 5 minutes. Subsequently, 7.5 mmol DCDMH was added in five portions over 1 hour and the reaction mixture was stirred at 35°C for 12 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue was added 20 mL of ethyl acetate, followed by washing the ethyl acetate layer twice with water (20 mL) and drying with anhydrous Na2SO4. After drying, the mixture was filtered and the solvent was removed under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent ratio of petroleum ether/ethyl acetate=20/1, v/v) to afford the target product ethyl 2,2-dichloro-3-oxobutanoate.
References
[1] Tetrahedron Letters, 2009, vol. 50, # 4, p. 473 - 475
[2] Tetrahedron Letters, 2005, vol. 46, # 28, p. 4749 - 4751
[3] Tetrahedron, 2014, vol. 70, # 52, p. 9814 - 9818
[4] Synthetic Communications, 2002, vol. 32, # 24, p. 3711 - 3717
[5] Green Chemistry, 2009, vol. 11, # 2, p. 275 - 278
ethyl 2,2-dichloroacetoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ethyl 2,2-dichloroacetoacetate manufacturers
- Product
- Amlodipine Impurity 27
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-06-13