guluronic acid
- Product Name
- guluronic acid
- CAS No.
- 15769-56-9
- Chemical Name
- guluronic acid
- Synonyms
- G2013;guluronic acid;Einecs 239-860-9;Guluronic acid sodium salt;L-Guluronic Acid Sodium Salt/Guluronic acid;L-Monoguluronic Acid Sodium Salt, Mono-Guluronic Acid Sodium Salt
- CBNumber
- CB8930228
- Molecular Formula
- C6H10O7
- Formula Weight
- 194.14
- MOL File
- 15769-56-9.mol
guluronic acid Property
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/t2-,3-,4+,5-/m0/s1
- InChIKey
- IAJILQKETJEXLJ-KLVWXMOXSA-N
- SMILES
- O=C[C@@H]([C@@H]([C@H]([C@@H](C(O)=O)O)O)O)O
guluronic acid Chemical Properties,Usage,Production
Description
Glucuronic acid is a sugar acid derived from glucose, with its sixth carbon atom oxidized to a carboxylic acid. In living beings, this primary oxidation occurs with UDP-α-D-glucose (UDPG), not with the free sugar.
Glucuronic acid, like its precursor glucose, can exist as a linear (carboxo-)aldohexose (<1%), or as a cyclic hemiacetal (furanose or pyranose). Aldohexoses such as D-glucose are capable of forming two furanose forms (α and β) and two pyranose forms (α and β). By the Fischer convention, glucuronic acid has two stereoisomers (enantiomers), D- and L-glucuronic acid, depending on its configuration at C-5. Most physiological sugars are of the D-configuration. Due to ring closure, cyclic sugars have another asymmetric carbon atom (C-1), resulting in two more stereoisomers, named anomers. Depending on the configuration at C-1, there are two anomers of glucuronic acid, α- and β-form. In β-D-glucuronic acid the C-1 hydroxy group is on the same side of the pyranose ring as the carboxyl group. In the free sugar acid, the β-form is prevalent (~64%), whereas in the organism, the α-form UDP-α-D-glucuronic acid (UDPGA) predominates.
Uses
Guluronic acid (G2013), one of the organic building blocks of hyaluronic acid, is a nonsteroidal anti-inflammatory agent has favorable anti-inflammatory effect[1][2].
References
[1] Amaniampong PN, et al. Selective and Catalyst-free Oxidation of D-Glucose to D-Glucuronic acid induced by High-Frequency Ultrasound. Sci Rep. 2017;7:40650. Published 2017 Jan 13. DOI:10.1038/srep40650
[2] Nazeri S, et al. The safety and efficacy of Guluronic acid (G2013) in ankylosing spondylitis: A randomized controlled parallel clinical trial. Pharmacol Rep. 2019;71(3):393-398. DOI:10.1016/j.pharep.2019.02.002
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View Lastest Price from guluronic acid manufacturers
- Product
- Guluronic acid 15769-56-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19