ChemicalBook > CAS DataBase List > pipamazine

pipamazine

Product Name
pipamazine
CAS No.
84-04-8
Chemical Name
pipamazine
Synonyms
SC 9387;RP-9153;Nometine;Nausidol;Mornidine;pipamazine;pipamazine USP/EP/BP;1-[3-(2-chlorophenothiazin-10-yl)propyl]isonipecotamide;1-[3-(2-chlorophenothiazin-10-yl)propyl]piperidine-4-carboxamide;4-Piperidinecarboxamide, 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-
CBNumber
CB8938956
Molecular Formula
C21H24ClN3OS
Formula Weight
401.95
MOL File
84-04-8.mol
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pipamazine Property

Melting point:
about 139°
Boiling point:
626.6±55.0 °C(Predicted)
Density 
1.1253 (rough estimate)
refractive index 
1.6340 (estimate)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
pKa 8.60(H2O,t =24±1,I=0.002) (Uncertain)
color 
Off-White to Pale Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
P475190
Product name
Pipamazine
Packaging
100mg
Price
$90
Updated
2021/12/16
TRC
Product number
P475190
Product name
Pipamazine
Packaging
1g
Price
$655
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
72046
Product name
Pipamazine
Packaging
10g
Price
$2120
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012254
Product name
PIPAMAZINE
Purity
95.00%
Packaging
5MG
Price
$498.26
Updated
2021/12/16
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pipamazine Chemical Properties,Usage,Production

Originator

Mornidine ,Searle ,US ,1959

Uses

Pipamazine is a drug od the phenothiazine class which used to be used as an antiemetic.

Definition

ChEBI: Pipamazine is a member of phenothiazines.

Manufacturing Process

To a stirred and refluxing suspension of 4.95 parts of 4piperidinecarboxamide, 1 part of sodium iodide and 8.4 parts of potassium carbonate in 40 parts of butanone there are added in the course of 30 minutes 9.3 parts of 2-chloro-10-(γ-chloropropyl)phenothiazine in 40 parts ofbutanone. Stirring and refluxing are continued for 12 hours after which the mixture is cooled and filtered. The filtrate is concentrated under vacuum to give a residue which is recrystallized from a mixture of 2-propanol and petroleum ether. The 1-[γ-(2'-chloro-10'-phenothiazine)propyl]piperidine-4carboxamide thus obtained melts at approximately 139°C.
This base is dissolved in a small amount of 2-propanol and treated with a 25% solution of hydrogen chloride in 2-propanol. Upon treatment of this solution with anhydrous ether a hydrochloride precipitates as a white solid melting at about 196°C to 197°C with formation of bubbles.

brand name

Normetine;.

Therapeutic Function

Antiemetic

World Health Organization (WHO)

Pipamazine, which is pharmacologically similar to chlorpromazine, was introduced in 1959 for the treatment of nausea and vomiting. Although it was withdrawn in 1969 by the United States FDA on grounds of lack of proof of efficacy and safety, it remains available in some countries.

pipamazine Preparation Products And Raw materials

Raw materials

Preparation Products

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pipamazine Suppliers

Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-87569265 +86-15319487004
Fax
029-88380327
Email
1015@dideu.com
Country
China
ProdList
2130
Advantage
58
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
68144
Advantage
58
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View Lastest Price from pipamazine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
pipamazine 84-04-8
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-06

84-04-8, pipamazine Related Search:


  • pipamazine
  • Mornidine
  • Nausidol
  • Nometine
  • RP-9153
  • SC 9387
  • 1-[3-(2-chlorophenothiazin-10-yl)propyl]isonipecotamide
  • 1-[3-(2-chlorophenothiazin-10-yl)propyl]piperidine-4-carboxamide
  • pipamazine USP/EP/BP
  • 4-Piperidinecarboxamide, 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-
  • 84-04-8