pipamazine
- Product Name
- pipamazine
- CAS No.
- 84-04-8
- Chemical Name
- pipamazine
- Synonyms
- SC 9387;RP-9153;Nometine;Nausidol;Mornidine;pipamazine;pipamazine USP/EP/BP;1-[3-(2-chlorophenothiazin-10-yl)propyl]isonipecotamide;1-[3-(2-chlorophenothiazin-10-yl)propyl]piperidine-4-carboxamide;4-Piperidinecarboxamide, 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-
- CBNumber
- CB8938956
- Molecular Formula
- C21H24ClN3OS
- Formula Weight
- 401.95
- MOL File
- 84-04-8.mol
pipamazine Property
- Melting point:
- about 139°
- Boiling point:
- 626.6±55.0 °C(Predicted)
- Density
- 1.1253 (rough estimate)
- refractive index
- 1.6340 (estimate)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- pKa 8.60(H2O,t =24±1,I=0.002) (Uncertain)
- color
- Off-White to Pale Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P475190
- Product name
- Pipamazine
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- P475190
- Product name
- Pipamazine
- Packaging
- 1g
- Price
- $655
- Updated
- 2021/12/16
- Product number
- 72046
- Product name
- Pipamazine
- Packaging
- 10g
- Price
- $2120
- Updated
- 2021/12/16
- Product number
- API0012254
- Product name
- PIPAMAZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.26
- Updated
- 2021/12/16
pipamazine Chemical Properties,Usage,Production
Originator
Mornidine ,Searle ,US ,1959
Uses
Pipamazine is a drug od the phenothiazine class which used to be used as an antiemetic.
Definition
ChEBI: Pipamazine is a member of phenothiazines.
Manufacturing Process
To a stirred and refluxing suspension of 4.95 parts of 4piperidinecarboxamide, 1 part of sodium iodide and 8.4 parts of potassium carbonate in 40 parts of butanone there are added in the course of 30 minutes 9.3 parts of 2-chloro-10-(γ-chloropropyl)phenothiazine in 40 parts ofbutanone. Stirring and refluxing are continued for 12 hours after which the mixture is cooled and filtered. The filtrate is concentrated under vacuum to give a residue which is recrystallized from a mixture of 2-propanol and petroleum ether. The 1-[γ-(2'-chloro-10'-phenothiazine)propyl]piperidine-4carboxamide thus obtained melts at approximately 139°C.
This base is dissolved in a small amount of 2-propanol and treated with a 25% solution of hydrogen chloride in 2-propanol. Upon treatment of this solution with anhydrous ether a hydrochloride precipitates as a white solid melting at about 196°C to 197°C with formation of bubbles.
brand name
Normetine;.
Therapeutic Function
Antiemetic
World Health Organization (WHO)
Pipamazine, which is pharmacologically similar to chlorpromazine, was introduced in 1959 for the treatment of nausea and vomiting. Although it was withdrawn in 1969 by the United States FDA on grounds of lack of proof of efficacy and safety, it remains available in some countries.
pipamazine Preparation Products And Raw materials
Raw materials
Preparation Products
pipamazine Suppliers
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View Lastest Price from pipamazine manufacturers
- Product
- pipamazine 84-04-8
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-06