2,3-dichloro-6-methoxypyridine
- Product Name
- 2,3-dichloro-6-methoxypyridine
- CAS No.
- 83732-68-7
- Chemical Name
- 2,3-dichloro-6-methoxypyridine
- Synonyms
- Einecs 280-618-7;Pyridine, 2,3-dichloro-6-methoxy-
- CBNumber
- CB8941187
- Molecular Formula
- C6H5Cl2NO
- Formula Weight
- 178.02
- MOL File
- 83732-68-7.mol
2,3-dichloro-6-methoxypyridine Property
- Boiling point:
- 219℃
- Density
- 1.363
- Flash point:
- 86℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.37±0.10(Predicted)
- Appearance
- White to off-white Crystal
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- HCH0351594
- Product name
- 2,3-DICHLORO-6-METHOXYPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.62
- Updated
- 2021/12/16
- Product number
- OR345420
- Product name
- 2,3-Dichloro-6-methoxypyridine
- Packaging
- 1g
- Price
- $653
- Updated
- 2021/12/16
- Product number
- OR345420
- Product name
- 2,3-Dichloro-6-methoxypyridine
- Packaging
- 250mg
- Price
- $279
- Updated
- 2021/12/16
- Product number
- D6610
- Product name
- 2,3-dichloro-6-methoxy-Pyridine
- Purity
- 97.00%
- Packaging
- 5G
- Price
- $330
- Updated
- 2021/12/16
- Product number
- D6610
- Product name
- 2,3-dichloro-6-methoxy-Pyridine
- Purity
- 97.00%
- Packaging
- 10G
- Price
- $480
- Updated
- 2021/12/16
2,3-dichloro-6-methoxypyridine Chemical Properties,Usage,Production
Synthesis
34392-85-3
83732-68-7
The general procedure for the synthesis of 2,3-dichloro-6-methoxypyridine from 2-chloro-3-amino-6-methoxypyridine was as follows: 3-amino-2-chloro-6-methoxypyridine (500 mg, 3.17 mmol) was dissolved or suspended in a conical flask. Hydrochloric acid (10 mL) was stirred at -5°C while an aqueous solution of sodium nitrite (1.09 g, 15.82 mmol) was added slowly and dropwise (5 mL) over 10 minutes. After continuing to stir the reaction mixture for 10 min, copper chloride (3.13 g, 31.65 mmol) was added in batches over 5 min. The reaction mixture was stirred at -5 °C for 20 min, after which the cooling bath was removed and the mixture was allowed to continue stirring for 3 h at room temperature. Upon completion of the reaction, the mixture was diluted with distilled water (100 mL), the pH was adjusted to 10-11 with 5N aqueous sodium hydroxide solution, and then extracted with ether (3 x 50 mL). The organic phases were combined, washed with saturated saline, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent of ethyl acetate:heptane (1:9, v/v) to afford the target product 2,3-dichloro-6-methoxypyridine as a light yellow oil (229 mg, 41% yield). The product was analyzed by mass spectrometry (ESI), m/z: 178 ([M + H]+).
References
[1] Patent: WO2007/39563, 2007, A1. Location in patent: Page/Page column 26
[2] Patent: US2007/112019, 2007, A1. Location in patent: Page/Page column 13/2
[3] Patent: WO2005/7648, 2005, A2. Location in patent: Page 87
2,3-dichloro-6-methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2,3-dichloro-6-methoxypyridine Suppliers
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 2805
- Advantage
- 65
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 025-52161033 15312098939
- Fax
- 025-83254025
- sales@njdrschem.com
- Country
- China
- ProdList
- 578
- Advantage
- 64
- Tel
- 0531-88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com
- Country
- China
- ProdList
- 1856
- Advantage
- 62
- Tel
- 0531-81313138 13066006660
- Fax
- QQ: 3366077777
- chibapharm@foxmail.com
- Country
- China
- ProdList
- 3991
- Advantage
- 55
- Tel
- +86-512-86881668
- Fax
- +86-512-62956001
- Country
- China
- ProdList
- 100
- Advantage
- 58
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 0512-0512-52358471 17715136450
- Fax
- 05125235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 12127
- Advantage
- 58
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 7218
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58