5-Nitro-1-tetralone
- Product Name
- 5-Nitro-1-tetralone
- CAS No.
- 51114-73-9
- Chemical Name
- 5-Nitro-1-tetralone
- Synonyms
- 5-NITRO-A-TETRALONE;5-Nitro-α-tetralone;5-Nitro-1-tetralone;5-Nitro-3,4-dihydronaphthalen-1(2H);5-nitro-3,4-dihydronaphthalen-1(2H)-one;3,4-dihydro-5-nitronaphthalen-1(2H)-one;5-Nitro-3,4-dihydro-2H-naphthalen-1-one;1(2H)-Naphthalenone, 3,4-dihydro-5-nitro-;5-nitro-1,2,3,4-tetrahydronaphthalen-1-one
- CBNumber
- CB8948030
- Molecular Formula
- C10H9NO3
- Formula Weight
- 191.18
- MOL File
- 51114-73-9.mol
5-Nitro-1-tetralone Property
- Melting point:
- 103-104 °C
- Boiling point:
- 349.9±31.0 °C(Predicted)
- Density
- 1.322±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to light yellow Solid
N-Bromosuccinimide Price
- Product number
- N901308
- Product name
- 5-Nitro-3,4-dihydronaphthalen-1(2H)-one
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-0060664
- Product name
- 5-Nitro-3,4-dihydro-2H-naphthalen-1-one
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-0060664
- Product name
- 5-Nitro-3,4-dihydro-2H-naphthalen-1-one
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 35462
- Product name
- 5-Nitro-3,4-dihydronaphthalen-1(2H)-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $572
- Updated
- 2021/12/16
- Product number
- CHM0078884
- Product name
- 3,4-DIHYDRO-5-NITRONAPHTHALEN-1(2H)-ONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1212.75
- Updated
- 2021/12/16
5-Nitro-1-tetralone Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of Medicinal Chemistry, 19, p. 472, 1976 DOI: 10.1021/jm00226a004
Synthesis
67857-97-0
51114-73-9
The general procedure for the synthesis of 5-nitro-α-tetralone from 4-(2-nitrophenyl)butyric acid was as follows: first, 1 g of 4-(2-nitrophenyl)butyric acid (NPBS, 4.78 mmol) and 18 g of trifluoromethanesulfonic acid (TFMS) were added to a 100 mL two-necked flask fitted with a reflux condenser and magnetic stirrer at 20 °C. Under stirring, the reaction mixture was placed in an oil bath preheated to 130 °C and stirred continuously at this temperature for 45 min. Upon completion of the reaction, the mixture was cooled and transferred to a microdistillation unit. Most of the excess TFMS was removed by distillation at 52 °C and 0.5 mbar.After distillation, the bottom residue contained 0.914 g of 5-nitro-3,4-dihydro-1(2H)-naphthalenone and 3.44 g of TFMS (as determined by the GC-ISTD/internal standard method) in 99.3% yield, with 100% conversion to NPBS and 99.3% selectivity.
References
[1] Patent: EP1369412, 2003, A1. Location in patent: Page 6
[2] Patent: EP1369412, 2003, A1. Location in patent: Page 6
[3] Patent: US2003/176722, 2003, A1
5-Nitro-1-tetralone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Nitro-1-tetralone manufacturers
- Product
- 5-Nitro-1-tetralone 51114-73-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-17