1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate
- Product Name
- 1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate
- CAS No.
- 57699-88-4
- Chemical Name
- 1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate
- Synonyms
- 1-Boc-2-Cbz-hydrazine;N-Boc-N'-Cbz-hydrazine;N-Boc-N’-Cbz-hydrazine;Hydrazine, N-BOC, N'-CBZ protected;1-benzyl 2-(tert-butyl) 1,2-hydrazinedicarboxylate;1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate;benzyl N-[(2-methylpropan-2-yl)oxycarbonylamino]carbamate;1,2-Hydrazinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-(phenylMethyl) ester
- CBNumber
- CB8956291
- Molecular Formula
- C13H18N2O4
- Formula Weight
- 266.29
- MOL File
- 57699-88-4.mol
1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate Property
- Melting point:
- 79-80
- Boiling point:
- 378.9±21.0 °C(Predicted)
- Density
- 1.160±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- crystalline powder
- pka
- 8.85±0.43(Predicted)
- color
- White
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B694713
- Product name
- 1-Benzyl2-(tert-butyl)hydrazine-1,2-dicarboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 046067
- Product name
- 1-Benzyl 2-(tert-butyl) 1,2-hydrazinedicarboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- OR12453
- Product name
- Hydrazine,N-BOC,N'-CBZprotected
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
- Product number
- J50967
- Product name
- 1-Benzyl2-(tert-butyl)hydrazine-1,2-dicarboxylate
- Packaging
- 1g
- Price
- $44
- Updated
- 2021/12/16
- Product number
- 4756-1-Z0
- Product name
- Hydrazine, N-Boc, N'-Cbz protected
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate Chemical Properties,Usage,Production
Uses
1-Benzyl 2-(tert-Butyl) Hydrazine-1,2-dicarboxylate is a useful intermediate for the preparation of some α-aza-amino-acid derivatives used in peptide synthesis.
Synthesis
870-46-2
501-53-1
57699-88-4
Benzyl chloroformate (Benzyl chloroformate) was slowly added to a solution of tert-butyl carbazate (tert-Butyl carbazate, 75 g, 567 mmol) in dichloromethane (Dichloromethane, 2.0 L) at 0 °C, and the addition time was controlled to be within 45 min. After the addition was completed, the reaction mixture was stirred at 0 °C overnight and allowed to warm up to room temperature naturally in an ice bath. Upon completion of the reaction, the reaction mixture was carefully poured into saturated sodium bicarbonate solution (1 L) for neutralization, followed by extraction with dichloromethane. The organic layer was washed with water and dried with anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to afford the crude product 2-(tert-butyl)hydrazine-1,2-dicarboxylic acid-1-benzyl ester (148 g, 556 mmol, 98% yield) as a viscous oil. After preliminary analysis, the purity of the product meets the requirements for subsequent use without further purification.
References
[1] Patent: WO2008/65500, 2008, A2. Location in patent: Page/Page column 67
[2] Tetrahedron, 2010, vol. 66, # 49, p. 9538 - 9544
[3] Tetrahedron Letters, 1992, vol. 33, # 36, p. 5209 - 5212
[4] Tetrahedron Letters, 2007, vol. 48, # 33, p. 5767 - 5770
[5] Journal of the American Chemical Society, 2004, vol. 126, # 21, p. 6759 - 6764
1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate manufacturers
- Product
- 1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate 57699-88-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20