4-Fluoroisoquinoline
- Product Name
- 4-Fluoroisoquinoline
- CAS No.
- 394-67-2
- Chemical Name
- 4-Fluoroisoquinoline
- Synonyms
- 4-fluoroisoquinoline sulfate;4-FLUOROISOQUINOLINE;4-Floro isoquinoli11e;Isoquinoline, 4-fluoro-;4-Fluoroisoquinoline 95+%;4-Fluoroisoquinoline ISO 9001：2015 REACH
- CBNumber
- CB8971782
- Molecular Formula
- C9H6FN
- Formula Weight
- 147.15
- MOL File
- 394-67-2.mol
4-Fluoroisoquinoline Property
- Melting point:
- 34 °C
- Boiling point:
- 240℃
- Density
- 1.216
- refractive index
- 1.5914
- Flash point:
- 99℃
- storage temp.
- 2-8°C
- form
- powder to lump
- pka
- 3.45±0.10(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C9H6FN/c10-9-6-11-5-7-3-1-2-4-8(7)9/h1-6H
- InChIKey
- VFFQGPWQVYUFLV-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=CC=C2)C(F)=CN=1
Safety
- HS Code
- 2933491090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- F1057
- Product name
- 4-Fluoroisoquinoline
- Packaging
- 250MG
- Price
- $155
- Updated
- 2025/07/31
- Product number
- B435208
- Product name
- 4-Fluoroisoquinoline
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC250003
- Product name
- 4-Fluoroisoquinoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $66
- Updated
- 2021/12/16
- Product number
- 3H32-3-7Q
- Product name
- 4-Fluoroisoquinoline
- Packaging
- 1g
- Price
- $106
- Updated
- 2021/12/16
- Product number
- Y5413
- Product name
- 4-Fluoroisoquinoline
- Packaging
- 1g
- Price
- $161
- Updated
- 2021/12/16
4-Fluoroisoquinoline Chemical Properties,Usage,Production
Uses
4-fluoroisoquinoline is a useful research chemical.
Synthesis
1532-97-4
394-67-2
General procedure for the synthesis of 4-fluoroisoquinoline from 4-bromoisoquinoline: A solution of 4-bromoisoquinoline (20 g, 96.6 mmol) dissolved in 144 mL of THF was added slowly and dropwise to a 760 mL THF solution containing n-butyllithium (133 mL, 332.5 mmol, 2.5 M in THF) at -65 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at -65 °C for 30 min. Subsequently, a solution of N-fluorobenzenesulfonimide (66.68 g, 211.7 mmol) dissolved in 216 mL THF was added dropwise at the same temperature. After addition, the reaction was maintained at -65 °C for 1 hour. Upon completion of the reaction, the mixture was slowly warmed to room temperature and the reaction was quenched by the addition of 300 mL of saturated aqueous ammonium chloride. The reaction mixture was extracted with ethyl acetate (300 mL x 3), and the combined organic phases were washed with 300 mL of saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (elution gradient: 0-100% ethyl acetate/petroleum ether) to afford 4-fluoroisoquinoline (8.5 g, red oil, yield: 60%).
References
[1] Journal of the American Chemical Society, 2014, vol. 136, # 10, p. 3792 - 3795
[2] Patent: US2017/37050, 2017, A1. Location in patent: Paragraph 0301; 0302
[3] Patent: US2007/179127, 2007, A1. Location in patent: Page/Page column 47-48
[4] Patent: US2009/48223, 2009, A1. Location in patent: Page/Page column 101
[5] Patent: US2010/93789, 2010, A1. Location in patent: Page/Page column 46
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Raw materials
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View Lastest Price from 4-Fluoroisoquinoline manufacturers
- Product
- 4-Fluoroisoquinoline 394-67-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-19
- Product
- 4-Fluoroisoquinoline 394-67-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98
- Supply Ability
- 100
- Release date
- 2024-10-22
- Product
- 4-Fluoroisoquinoline 394-67-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-23