ChemicalBook > CAS DataBase List > O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7

O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7

Product Name: O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7
CAS No.: 846549-37-9
Chemical Name: O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7
Synonyms: N3-(PEG)7-COOH;azido-peg-acid (n=8);N-(PEG)-COOH (33 atoms);N3-PEG8-NHCOCH2OCH2COOH;Azido-PEG8-NHCOCH2OCH2COOH;N3-PEG8-CH2CH2NHCOCH2OCH2COOH;N3-(PEG)7-COOH (33 ATOMS) 1 G;N-(PEG)-COOH (33 atoms) Novabiochem;2-((Azido-PEG8-carbamoyl)methoxy)acetic acid;-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7
CBNumber: CB8972491
Molecular Formula: C22H42N4O12
Formula Weight: 554.59
MOL File: 846549-37-9.mol

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O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 Property

storage temp.: Store at +2°C to +8°C.
form: Liquid
color: Colorless to light yellow
InChI: InChI=1S/C22H42N4O12/c23-26-25-2-4-31-6-8-33-10-12-35-14-16-37-18-17-36-15-13-34-11-9-32-7-5-30-3-1-24-21(27)19-38-20-22(28)29/h1-20H2,(H,24,27)(H,28,29)
InChIKey: WWDNBBVPYDZICO-UHFFFAOYSA-N
SMILES: C(CNC(=O)COCC(=O)O)OCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 25
WGK Germany: 3
HS Code: 2929 90 00

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.51021
Product name: N₃-(PEG)₇-COOH (33 atoms)
Purity: Novabiochem?
Packaging: 1g
Price: $717
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51021
Product name: N₃-(PEG)₇-COOH (33 atoms)
Purity: Novabiochem®
Packaging: 100 g
Price: $35860
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51021
Product name: N₃-(PEG)₇-COOH (33 atoms)
Purity: Novabiochem®
Packaging: 100 g
Price: $35860
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51021
Product name: N₃-(PEG)₇-COOH (33 atoms)
Purity: Novabiochem®
Packaging: 250 g
Price: $83690
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51021
Product name: N₃-(PEG)₇-COOH (33 atoms)
Purity: Novabiochem®
Packaging: 250 g
Price: $83690
Updated: 2025/07/31

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O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 Chemical Properties,Usage,Production

Description

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG linker containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid 846549-37-9
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-06

R&D Scientific Inc.

Product: 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid 846549-37-9
Price: US $720.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 1 Kg
Release date: 2024-02-11

846549-37-9, O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7Related Search:

O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)HEPTAETHYLENE GLYCOL O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 HEPTAETHYLENE GLYCOL Glycolamide, N,N-bis(2-hydroxyethyl)-

O-(2-Azidoethyl)-O-[2-(diglycoly-amino)ethyl]heptaethylene glycol

N-(PEG)-COOH (33 atoms)

O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7

azido-peg-acid (n=8)

N3-(PEG)7-COOH

N-(PEG)-COOH (33 atoms) Novabiochem

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid

O-(2-Azidoethyl)-O-[2-(diglycolyl-aMino)ethyl]heptaethylene glycol >=90% (oligoMer purity)

N3-(PEG)7-COOH (33 ATOMS) 1 G

2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetic acid

N3-PEG8-CH2CH2NHCOCH2OCH2COOH

-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7

N3-PEG8-CH2CH2NHCOCH2OCH2COOH/Acetic acid,2-[(29-azido-2-oxo-6,9,12,15,18,21,24,27-octaoxa-3-azanonacos-1-yl)oxy]-

32-Azido-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontanoic acid

Azido-PEG8-NHCOCH2OCH2COOH

N3-PEG8-NHCOCH2OCH2COOH

2-{[(26-azido-3,6,9,12,15,18,21,24-octaoxahexacosan-1-yl)carbamoyl]methoxy}acetic acid

32-Azido-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontan-1-oic Acid

O-(2-Azidoethyl)-O-[2-(diglycolyl-amino)ethyl]heptaethylene glycol - [A72679]

846549-37-9

C22H42N4O12

peg