4-(TRIMETHYLSILYLETHYNYL)BENZYL ALCOHOL
- Product Name
- 4-(TRIMETHYLSILYLETHYNYL)BENZYL ALCOHOL
- CAS No.
- 275386-60-2
- Chemical Name
- 4-(TRIMETHYLSILYLETHYNYL)BENZYL ALCOHOL
- Synonyms
- 4-(Trimethylsilylethynyl)benzyl alcohol 97%;4-((2-Trimethylsilyl)ethynyl)benzyl alcohol;(4-((TriMethylsilyl)ethynyl)phenyl)Methanol;4-[2-(Trimethylsilyl)ethynyl]benzenemethanol;[4-(2-Trimethylsilylethynyl)Phenyl] Methanol;Benzenemethanol, 4-[2-(trimethylsilyl)ethynyl]-;4-
(Trimethylsilylethynyl) benzyl alcohol;(4-((Trimethylsilyl)ethynyl)phenyl)methanol - [T56112] - CBNumber
- CB8972693
- Molecular Formula
- C12H16OSi
- Formula Weight
- 204.34
- MOL File
- 275386-60-2.mol
4-(TRIMETHYLSILYLETHYNYL)BENZYL ALCOHOL Property
- Melting point:
- 68-72 °C
- Boiling point:
- 274.6±32.0 °C(Predicted)
- Density
- 0.99±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 14.46±0.10(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 668273
- Product name
- 4-(Trimethylsilylethynyl)benzyl alcohol
- Purity
- 97%
- Packaging
- 5g
- Price
- $283
- Updated
- 2025/07/31
- Product number
- T899813
- Product name
- (4-((Trimethylsilyl)ethynyl)phenyl)methanol
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- AS88728
- Product name
- 4-[2-(Trimethylsilyl)ethynyl]benzenemethanol
- Purity
- 95%
- Packaging
- 1g
- Price
- $129
- Updated
- 2021/12/16
- Product number
- T56112
- Product name
- (4-((Trimethylsilyl)ethynyl)phenyl)methanol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- T56112
- Product name
- (4-((Trimethylsilyl)ethynyl)phenyl)methanol
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $15
- Updated
- 2021/12/16
4-(TRIMETHYLSILYLETHYNYL)BENZYL ALCOHOL Chemical Properties,Usage,Production
Synthesis
873-75-6
1066-54-2
275386-60-2
GENERAL STEPS: To an anhydrous triethylamine (TEA) solution of 4-bromobenzyl alcohol (935 mg, 5 mmol) was sequentially added dichlorobis(triphenylphosphine)palladium(II) (Pd(PPh3)2Cl2, 175 mg, 0.25 mmol), cuprous iodide (CuI, 48 mg, 0.25 mmol) and tri-tert-butylphosphine (P(t-Bu)3, 51 mg. 0.25 mmol) and stirred for 5 min under nitrogen (N2) protection. Subsequently, trimethylsilylacetylene (980 mg, 10 mmol) was added slowly and dropwise. The reaction mixture was placed in a microwave reactor and heated at 130 °C for 4 hours. After completion of the reaction, it was cooled to room temperature and filtered through diatomaceous earth. The filtrate was concentrated under reduced pressure and the residue was extracted three times with ethyl acetate (EtOAc) and water (H2O). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4), and then purified by silica gel column chromatography (petroleum ether/ethyl acetate, 4:1) to afford 4-(trimethylsilylethynyl)benzylmethanol (670 mg, 66%) as a brown oil. To a solution of 4-(trimethylsilylethynyl)benzylmethanol (250 mg, 1.23 mmol) in tetrahydrofuran (THF) was added tetrabutylammonium fluoride (TBAF, 500 mg, 2.45 mmol) in batches. The reaction mixture was stirred at 0 °C, gradually warmed to room temperature and continued stirring for 3 hours. After completion of the reaction, the solvent was removed under reduced pressure and the residue was extracted three times with ethyl acetate (EtOAc) and water (H2O). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4), and then purified by silica gel column chromatography (petroleum ether/ethyl acetate, 4:1) to afford 4-ethynylbenzylmethanol (170 mg, 100%) as a brown oil.1H NMR (400 MHz, CDCl3) δ 7.45-7.49 (m, 2H), 7.21- 7.26 (m, 2H), 4.69 (s, 1H), 4.65 (s, 2H).
References
[1] Chemistry - A European Journal, 2017, vol. 23, # 50, p. 12190 - 12197
[2] Synthesis (Germany), 2014, vol. 46, # 3, p. 348 - 356
[3] Angewandte Chemie - International Edition, 2004, vol. 43, # 29, p. 3814 - 3818
[4] Patent: WO2018/14802, 2018, A1. Location in patent: Paragraph 0364
[5] Chemistry - A European Journal, 2013, vol. 19, # 29, p. 9452 - 9456
4-(TRIMETHYLSILYLETHYNYL)BENZYL ALCOHOL Preparation Products And Raw materials
Raw materials
Preparation Products
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