PTACH
- Product Name
- PTACH
- CAS No.
- 848354-66-5
- Chemical Name
- PTACH
- Synonyms
- NCH 51;NCH51, >98%;PTACH?, >98%;PTACH (NCH-51);HDAC Inhibitor XXII, NCH51;HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem;Cpd 51, S-[6-(4-Phenyl-2-thiazolylcarbamoyl)hexyl] thioisobutyrate;S-(7-Oxo-7-((4-phenylthiazol-2-yl)amino)-heptyl) 2-methylpropanethioate;S-[7-oxo-7-[(4-phenyl-1,3-thiazol-2-yl)amino]heptyl] 2-methylpropanethioate;2-MethylpropanethioicacidS-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl]ester
- CBNumber
- CB8972794
- Molecular Formula
- C20H26N2O2S2
- Formula Weight
- 390.56
- MOL File
- 848354-66-5.mol
PTACH Property
- Melting point:
- 127-128 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))
- Density
- 1.181±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble26mg/mL
- form
- White powder
- pka
- 9.52±0.50(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 382185
- Product name
- HDAC Inhibitor XXII, NCH51
- Packaging
- 2mg
- Price
- $140
- Updated
- 2023/01/07
- Product number
- P5874
- Product name
- PTACH
- Purity
- ≥98% (HPLC), solid
- Packaging
- 2mg
- Price
- $286
- Updated
- 2022/05/15
- Product number
- 21234
- Product name
- NCH-51
- Purity
- ≥98%
- Packaging
- 1 mg
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 21234
- Product name
- NCH-51
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 21234
- Product name
- NCH-51
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
PTACH Chemical Properties,Usage,Production
Uses
NCH 51 is a Histone deacetylase inhibitor.
Definition
ChEBI: 2-methylpropanethioic acid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester is an aromatic amide.
General Description
A cell-permeable S-isobutyryl prodrug that is processed intracellularly to form the potent HDAC inhibitor NCH-31 (IC50 = 48 and 170 nM, respectively, using partially purified HDAC1 or HeLa nuclear extract) that is predicted to exhibit a similar HADC binding mode as that of SAHA with its sulfhydryl replacing SAHA′s hydroxamate as the active-site zinc-targeting group. NCH-51 is shown to exhibit comparable antiproliferative (mean IC50 = 3.8 μM vs. 3.7 μM for SAHA; 48 h treatment) and apoptotic activity as SAHA against various cancer cell lines, but not PBMCs from 4 healthy individuals (IC50 >30 μM with either drug), and the antioxidant N-Acetyl-L-Cysteine (NAC; Cat. No. 106425) at 2 mM is reported to abolish the cell-growth inhibition caused by either 3 μM NCH-51 or SAHA in the Multiple Myeloma U266 cultures. Half-life in human plasma at 37 °C = 24 h.
Biological Activity
Histone deacetylase (HDAC) inhibitor. Inhibits growth of various cancer cells in vitro (EC 50 = 1.1-9.1 μ M).
Biochem/physiol Actions
HDAC inhibitor; more potent than the majority of HDAC inhibitors except for SAHA (gold standard).
References
[1]. suzuki t, hisakawa s, itoh y, et al. identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor. bioorg med chem lett, 2007, 17(6): 1558-1561.
[2]. suzuki t, nagano y, kouketsu a, et al. novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of saha-based non-hydroxamates. j med chem, 2005, 48(4): 1019-1032.
[3]. sanda t, okamoto t, uchida y, et al. proteome analyses of the growth inhibitory effects of nch-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. leukemia, 2007, 21(11): 2344-2353.
[4]. victoriano af, imai k, togami h, et al. novel histone deacetylase inhibitor nch-51 activates latent hiv-1 gene expression. febs lett, 2011, 585(7): 1103-1111.
PTACH Preparation Products And Raw materials
Raw materials
Preparation Products
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