ChemicalBook > CAS DataBase List > LY 294002

LY 294002

Product Name: LY 294002
CAS No.: 934389-88-5
Chemical Name: LY 294002
Synonyms: LY 294002, HYDROCHLORIDE SALT;LY-294,002 hydrochloride【L9908】;LY 294002, Hydrochloride Salt, >99%;LY-294,002 hydrochloride, ≥98% (HPLC);LY-294002 hydrochloride, 10 mM in DMSO;2-Morpholin-4-yl-8-phenyl-4H-chromen-4-one HCl;2-morpholino-8-phenyl-4H-chromen-4-one hydrochloride;2-morpholin-4-yl-8-phenylchromen-4-one,hydrochloride;LY-294,002 hydrochloride, 98%, selective inhibitor of PI 3-kinase
CBNumber: CB8972820
Molecular Formula: C19H18ClNO3
Formula Weight: 343.80412
MOL File: 934389-88-5.mol

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LY 294002 Property

storage temp.: 2-8°C
solubility: DMSO: >5mg/mL
form: solid
color: white to off-white
biological source: microbial (Staphylococcus roseus)

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Safety

WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L9908
Product name: LY-294,002 hydrochloride
Purity: solid, ≥98% (HPLC)
Packaging: 1mg
Price: $76.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: L9908
Product name: LY-294,002 hydrochloride
Purity: solid, ≥98% (HPLC)
Packaging: 5mg
Price: $186.2
Updated: 2025/07/31

TRC

Product number: L503113
Product name: LY-294,002 hydrochloride
Packaging: 100mg
Price: $395
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0002442
Product name: LY 294002 HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $500.96
Updated: 2021/12/16

AK Scientific

Product number: 0286AQ
Product name: LY-294,002 hydrochloride
Packaging: 5mg
Price: $240
Updated: 2021/12/16

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LY 294002 Chemical Properties,Usage,Production

Uses

LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).

General Description

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

Biological Activity

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

in vivo

LY294002 hydrochloride (10, 25, 50, 75 mg/kg; i.p.; twice weekly; for 4 weeks) significantly reduces mean NPC tumor burden in a dose-dependent manner. LY294002 (10, 25 mg/kg) is less effective in decreasing tumor burden^[4].
LY294002 hydrochloride (1.2 mg/kg per day; i.p.; for 14 days) prevents Leptin (60 ug/kg)-induced adverse effects on spermatozoa in Sprague-Dawley rats^[5].

Animal Model:	Athymic nude mice (6-8 weeks) with CNE-2Z xenograft^[4]
Dosage:	10 mg/kg, 25 mg/kg, 50 mg/kg, and 75 mg/kg
Administration:	IP; twice weekly, for 4 weeks
Result:	Mean Nasopharyngeal carcinoma (NPC) tumor burden was remarkably decreased in a dose-dependent manner.

IC 50

CK2: 0.098 μM (IC₅₀); CK2α2: 3.869 μM (IC₅₀)

storage

Room temperature

LY 294002 Preparation Products And Raw materials

Raw materials

Preparation Products

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934389-88-5, LY 294002Related Search:

LY 294002, Hydrochloride Salt, >99%

LY 294002, HYDROCHLORIDE SALT

LY-294,002 hydrochloride, 98%, selective inhibitor of PI 3-kinase

LY-294,002 hydrochloride, ≥98% (HPLC)

2-morpholin-4-yl-8-phenylchromen-4-one,hydrochloride

2-morpholino-8-phenyl-4H-chromen-4-one hydrochloride

LY-294002 hydrochloride, 10 mM in DMSO

LY-294,002 hydrochloride【L9908】

2-Morpholin-4-yl-8-phenyl-4H-chromen-4-one HCl

934389-88-5

C19H17NO3HCl