NS8593 HYDROCHLORIDE

Product Name: NS8593 HYDROCHLORIDE
CAS No.: 875755-24-1
Chemical Name: NS8593 HYDROCHLORIDE
Synonyms: NS8593;NS8593 HCl;NS8593 HYDROCHLORIDE;N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine;: N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride;NS8593 hydrochloride,inhibit,NS8593,neurological,Ca2+,Inhibitor,hIK,SK1,SK2,KcsA,Potassium Channel,NS-8593,SK3,hBK,neurons,NS-8593 hydrochloride,dopaminergic,NS 8593,channel
CBNumber: CB8973069
Molecular Formula: C17H17N3.ClH
Formula Weight: 299.803
MOL File: 875755-24-1.mol

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NS8593 HYDROCHLORIDE Property

storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
form: powder
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 492031
Product name: NS8593
Purity: An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels in a Ca2+-dependent manner.
Packaging: 10MG
Price: $196
Updated: 2024/03/01

Sigma-Aldrich

Product number: N2538
Product name: NS8593 hydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $169
Updated: 2022/05/15

Sigma-Aldrich

Product number: N2538
Product name: NS8593 hydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $638
Updated: 2022/05/15

Cayman Chemical

Product number: 29774
Product name: NS 8593 (hydrochloride)
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 29774
Product name: NS 8593 (hydrochloride)
Packaging: 25mg
Price: $393
Updated: 2024/03/01

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NS8593 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

NS 8593 is an inhibitory gating modifier of small-conductance calcium-activated potassium (K_Ca2/SK) channels (K_ds = 0.42, 0.6, and 0.73 μM for K_Ca2.1/SK1, K_Ca2.2/SK2, and K_Ca2.3/SK3, respectively, in the presence of calcium) that decreases the calcium sensitivity of SK channels. It is selective for K_Ca2/SK channels over intermediate- (K_Ca3.1/IK_Ca1) and large-conductance (BK) potassium channels at 10 μM. NS 8593 induces relaxation of potassium- or acetylcholine chloride-precontracted isolated tracheal rings from wild-type mice (IC₅₀s = 8.9 and 39.8 μM, respectively) or from mice in an ovalbumin-induced model of allergic asthma (IC₅₀s = 16.4 and 32.2 μM, respectively). It inhibits aerosolized acetylcholine chloride-induced increases in respiratory system resistance in mice when administered as an aerosol at a dose of 500 μM. NS 8593 (5 mg/kg) decreases the duration of burst-pacing-induced atrial fibrillation in normotensive and spontaneously hypertensive rats.

Uses

NS8593 hydrochloride has been used to study its effect on the growth of MDA-MB-231 cells (M.D. Anderson and metastasis breast cancer cells).

Biochem/physiol Actions

The compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reversibly inhibited recombinant SK3-mediated currents (human and rat SK3) with potencies around 100 nM. NS8593 did not inhibit 125I-apamin binding. NS8593 decreased the calcium sensitivity by shifting the activation curve for Ca2+ to the right, only slightly affecting the maximal Ca2+-activated SK current. NS8593 inhibited all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+. NS8593 did not affect the calcium-activated potassium channels of intermediate and large conductance (hIK and hBK channels, respectively). NS8593-mediated inhibition was prevented in the presence of a high concentration of the positive modulator NS309.

storage

Store at +4°C

NS8593 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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NS8593 HYDROCHLORIDE Suppliers

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875755-24-1, NS8593 HYDROCHLORIDERelated Search:

NS8593 HYDROCHLORIDE

: N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride

NS8593

N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine

NS8593 HCl

NS8593 hydrochloride,inhibit,NS8593,neurological,Ca2+,Inhibitor,hIK,SK1,SK2,KcsA,Potassium Channel,NS-8593,SK3,hBK,neurons,NS-8593 hydrochloride,dopaminergic,NS 8593,channel

875755-24-1