ChemicalBook > CAS DataBase List > Baxdrostat

Baxdrostat

Product Name: Baxdrostat
CAS No.: 1428652-17-8
Chemical Name: Baxdrostat
Synonyms: RG-7641;CIN-107;RO-6836191;Baxdrostat;Baxdrostat, 10 mM in DMSO;(R)-N-(4-(1-Methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide;Propanamide, N-[(8R)-5,6,7,8-tetrahydro-4-(1,2,3,4-tetrahydro-1-methyl-2-oxo-6-quinolinyl)-8-isoquinolinyl]-;(+)-(R)-N-(4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide
CBNumber: CB89763124
Molecular Formula: C22H25N3O2
Formula Weight: 363.45
MOL File: 1428652-17-8.mol

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Baxdrostat Property

Boiling point:: 697.6±55.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
solubility: DMSO : 250 mg/mL (687.85 mM; Need ultrasonic)
pka: 15.05±0.20(Predicted)
form: Solid
color: Off-white to light yellow
InChI: InChI=1S/C22H25N3O2/c1-3-21(26)24-19-6-4-5-16-17(12-23-13-18(16)19)14-7-9-20-15(11-14)8-10-22(27)25(20)2/h7,9,11-13,19H,3-6,8,10H2,1-2H3,(H,24,26)/t19-/m1/s1
InChIKey: VDEUDSRUMNAXJG-LJQANCHMSA-N
SMILES: C(N[C@H]1C2=C(CCC1)C(C1C=CC3=C(C=1)CCC(=O)N3C)=CN=C2)(=O)CC

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Hazard and Precautionary Statements (GHS)

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Baxdrostat Chemical Properties,Usage,Production

Uses

Baxdrostat is a novel aldosterone synthase Inhibitor for treatment resistant hypertension and systemic Hypertension.

Mode of action

The mechanism of action of baxdrostat as an aldosterone synthase inhibitor demonstrates the inextricable linkage between sodium and blood pressure regulation. Baxdrostat significantly decreases aldosterone in plasma and urine, while increasing plasma renin as a physiological compensatory change.

Baxdrostat Preparation Products And Raw materials

Raw materials

Preparation Products

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1428652-17-8, BaxdrostatRelated Search:

Propanamide, N-[(8R)-5,6,7,8-tetrahydro-4-(1,2,3,4-tetrahydro-1-methyl-2-oxo-6-quinolinyl)-8-isoquinolinyl]-

Baxdrostat

(R)-N-(4-(1-Methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide

Baxdrostat, 10 mM in DMSO

RG-7641

RO-6836191

CIN-107

(+)-(R)-N-(4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide

1428652-17-8