9-Tetradecenoic acid, 1,1′-[2-[[4-(dimethylamino)-1-oxobutoxy]methyl]-2-[[[(9Z)-1-oxo-9-tetradecen-1-yl]oxy]methyl]-1,3-propanediyl] ester, (9Z,9′Z)-
- Product Name
- 9-Tetradecenoic acid, 1,1′-[2-[[4-(dimethylamino)-1-oxobutoxy]methyl]-2-[[[(9Z)-1-oxo-9-tetradecen-1-yl]oxy]methyl]-1,3-propanediyl] ester, (9Z,9′Z)-
- CAS No.
- 2361162-70-9
- Chemical Name
- 9-Tetradecenoic acid, 1,1′-[2-[[4-(dimethylamino)-1-oxobutoxy]methyl]-2-[[[(9Z)-1-oxo-9-tetradecen-1-yl]oxy]methyl]-1,3-propanediyl] ester, (9Z,9′Z)-
- Synonyms
- (9Z,9'Z)-2-(((4-(Dimethylamino)butanoyl)oxy)methyl)-2-(((Z)-tetradec-9-enoyloxy)methyl)propane-1,3-diyl bis(tetradec-9-enoate);(9Z,9'Z)-2-(((4-(Dimethylamino)butanoyl)oxy)methyl)-2-(((Z)-tetradec-9-enoyloxy)methyl)propane-1,3-diyl bis(tetradec-9-enoate);9-Tetradecenoic acid, 1,1′-[2-[[4-(dimethylamino)-1-oxobutoxy]methyl]-2-[[[(9Z)-1-oxo-9-tetradecen-1-yl]oxy]methyl]-1,3-propanediyl] ester, (9Z,9′Z)-
- CBNumber
- CB910023980
- Molecular Formula
- C53H95NO8
- Formula Weight
- 874.33
- MOL File
- 2361162-70-9.mol
9-Tetradecenoic acid, 1,1′-[2-[[4-(dimethylamino)-1-oxobutoxy]methyl]-2-[[[(9Z)-1-oxo-9-tetradecen-1-yl]oxy]methyl]-1,3-propanediyl] ester, (9Z,9′Z)- Property
- Boiling point:
- 813.3±65.0 °C(Predicted)
- Density
- 0.965±0.06 g/cm3(Predicted)
- solubility
- Ethanol: 25 mg/ml
- form
- Liquid
- pka
- 9.34±0.28(Predicted)
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
9-Tetradecenoic acid, 1,1′-[2-[[4-(dimethylamino)-1-oxobutoxy]methyl]-2-[[[(9Z)-1-oxo-9-tetradecen-1-yl]oxy]methyl]-1,3-propanediyl] ester, (9Z,9′Z)- Chemical Properties,Usage,Production
Description
TCL053 is an ionizable amino lipid. It has been used in the generation of lipid nanoparticles.
Uses
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle[1][2].
in vivo
TCL053-based LNP encapsulating Cas9 mRNA (TCL053-LNP-CRISPR) (20 μg total RNA; i.m.) exhibits high genome editing and exon skipping efficacy, and is higher than other in vivo mRNA delivery reagent (in vivo-jetRNA)[1].
TCL053-based LNP, via limb perfusion method, can target multiple muscle groups, with repeated administration and low immunogenicity features[1].
TCL053-based LNP acts as a delivery vehicle of CRISPR-Cas9 and can be used for skeletal muscle disorders research[1].
TCL053-based LNP induces stable genomic exon skipping and restore dystrophin protein in a DMD mouse model that harbors a humanized exon sequence[1].
References
[1] Kenjo E, et al. Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice. Nat Commun. 2021 Dec 8;12(1):7101.
[2] Cationic lipid. JPWO2019131839A1.
9-Tetradecenoic acid, 1,1′-[2-[[4-(dimethylamino)-1-oxobutoxy]methyl]-2-[[[(9Z)-1-oxo-9-tetradecen-1-yl]oxy]methyl]-1,3-propanediyl] ester, (9Z,9′Z)- Preparation Products And Raw materials
Raw materials
Preparation Products
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