SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE

Product Name: SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
CAS No.: 165377-44-6
Chemical Name: SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
Synonyms: SA-4503;CS-2246;SA-4503(2HCl);Cutamesine HCl;SA 4503;SA-4503;SA4503 >=98% (HPLC);Cutamesine hydrochloride;AGY94806 dihydrochloride;SA 4503 (dihydrochloride);Cutamesine dihydrochloride
CBNumber: CB91011619
Molecular Formula: C23H32N2O2.2ClH
Formula Weight: 441.44
MOL File: 165377-44-6.mol

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SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Property

Melting point:: 250-252°C
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 5 mg/ml) or in Water (up to at least 25 mg/ml)..
form: powder
color: white to beige
Water Solubility: H2O: 2mg/mL, clear
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2181
Product name: SA4503
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2181
Product name: SA4503
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $436
Updated: 2025/07/31

Cayman Chemical

Product number: 26241
Product name: SA 4503
Packaging: 10mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 26241
Product name: SA 4503
Packaging: 50mg
Price: $322
Updated: 2024/03/01

Cayman Chemical

Product number: 26241
Product name: SA 4503
Packaging: 5mg
Price: $56
Updated: 2024/03/01

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SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

SA4503 (165377-44-6) is a potent and selective sigma 1 agonist (σ1 IC50?= 17.4 nM, σ2 IC50?= 1784 nM).1?It has been investigated as a cognition enhancer2,3, antidepressant4,5, anti-addiction agent6, and neuroprotectant7-10.

Uses

SA 4503 Dihydrochloride is a novel and selective σ1 receptor agonist.

Biochem/physiol Actions

SA4503 is a high affinity, orally active non-opioid intracellular receptor sigma-1 (σ1R) selective agonist (IC50 = 17.4 nM against 200 nM (+)-pentazocine for binding σ1R), exhibiting ~100-fold less affinity for the sigma 2 receptor subtype (σ2R) and little or no affinity toward 36 other receptors, ion channels and second messenger systems. Oral administration is reported to elicit cerebral acetylcholine (ACh) release in rat frontal cortex and hippocampus (5-20 mg/kg p.o.) and reduce immobility time in a mouse forced swimming test (Immobility time = 214.8 s without vs. 111.6 s with 1.0 mg/kg oral dosage).

in vivo

Cutamesine extends the survival time in the SOD1G93A mice^[2].

IC 50

Sigma 1 Receptor

storage

Desiccate at RT

References

[1] KIYOSHI MATSUNO. Binding properties of SA4503, a novel and selective σ1 receptor agonist[J]. European journal of pharmacology, 1996, 306 1: Pages 271-279. DOI:10.1016/0014-2999(96)00201-4
[2] SA4503, a novel cognition enhancer with sigma 1 agonistic properties
[3] TOMIHISA NIITSU K H Masaomi Iyo. Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases.[J]. Current pharmaceutical design, 2012, 18 7: 875-883. DOI:10.2174/138161212799436476
[4] G SKUZA Z R. A potential antidepressant activity of SA4503, a selective sigma 1 receptor agonist.[J]. Behavioural Pharmacology, 2002, 13 7: 537-543. DOI:10.1097/00008877-200211000-00003
[5] GUILLAUME LUCAS. Further evidence for an antidepressant potential of the selective sigma1 agonist SA 4503: electrophysiological, morphological and behavioural studies.[J]. International Journal of Neuropsychopharmacology, 2008, 11 4: 485-495. DOI:10.1017/s1461145708008547
[6] TOMOHISA MORI. Inhibitory effects of SA4503 on the rewarding effects of abused drugs.[J]. Addiction Biology, 2014, 19 3: 362-369. DOI:10.1111/j.1369-1600.2012.00488.x
[7] MINAKO NAKAZAWA Shiro M Kiyoshi Matsuno. Activation of σ1 receptor subtype leads to neuroprotection in the rat primary neuronal cultures[J]. Neurochemistry international, 1998, 32 4: Pages 337-343. DOI:10.1016/s0197-0186(97)00105-8
[8] KARSTEN RUSCHER. The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.[J]. ACS Central Science, 2011: 732-746. DOI:10.1093/brain/awq367
[9] KARSTEN RUSCHER. Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke.[J]. ACS Applied Bio Materials, 2012: e45118. DOI:10.1371/journal.pone.0045118
[10] DAISUKE YAMASHITA. Neuroprotective effects of cutamesine, a ligand of the sigma-1 receptor chaperone, against noise-induced hearing loss[J]. Journal of Neuroscience Research, 2015, 93 5: 788-795. DOI:10.1002/jnr.23543

SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

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View Lastest Price from SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE 165377-44-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-09

165377-44-6, SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDERelated Search:

SKF 96365 HYDROCHLORIDE 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid JZL 184 Nalmefene hydrochloride 2-Methoxyphenylacetic acid 4'-Hydroxyacetophenone Sodium benzoate PIPERAZINE DIHYDROCHLORIDE PIPERAZINE DIHYDROCHLORIDE SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE 1-(2-PHENYLETHYL)PIPERAZINE 1-(3-PHENYLPROPYL)PIPERAZINE

1-[2-(3,4-DiMethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride

SA-4503

SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE

1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazinedihydrochloride

1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine hydrochloride

SA-4503(2HCl)

Cutamesine HCl (SA-4503 HCl)

SA 4503 (dihydrochloride)

Cutamesine dihydrochloride

Cutamesine HCl

Cutamesine hydrochloride

SA4503; SA 4503; SA-4503; AGY94806; AGY-94806; AGY 94806; CUTAMESINE HCL; CUTAMESINE HYDROCHLORIDE

AGY94806 dihydrochloride

SA4503 DIHYDROCHLORIDE;AGY94806 DIHYDROCHLORIDE

CS-2246

SA 4503;SA-4503

SA4503 >=98% (HPLC)

1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazin...

Cutamesine dihydrochloride, 10 mM in DMSO

Cutamesine (SA4503 ) dihydrochloride

165377-44-6

C23H32N2O22HCl

C23H34Cl2N2O2

C23H32N2O22ClH