SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
- Product Name
- SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
- CAS No.
- 165377-44-6
- Chemical Name
- SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
- Synonyms
- SA-4503;CS-2246;SA-4503(2HCl);Cutamesine HCl;SA 4503;SA-4503;SA4503 >=98% (HPLC);Cutamesine hydrochloride;AGY94806 dihydrochloride;SA 4503 (dihydrochloride);Cutamesine dihydrochloride
- CBNumber
- CB91011619
- Molecular Formula
- C23H32N2O2.2ClH
- Formula Weight
- 441.44
- MOL File
- 165377-44-6.mol
SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Property
- Melting point:
- 250-252°C
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 5 mg/ml) or in Water (up to at least 25 mg/ml)..
- form
- powder
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
N-Bromosuccinimide Price
- Product number
- SML2181
- Product name
- SA4503
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- SML2181
- Product name
- SA4503
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $424
- Updated
- 2024/03/01
- Product number
- 26241
- Product name
- SA 4503
- Packaging
- 10mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 26241
- Product name
- SA 4503
- Packaging
- 50mg
- Price
- $322
- Updated
- 2024/03/01
- Product number
- 26241
- Product name
- SA 4503
- Packaging
- 5mg
- Price
- $56
- Updated
- 2024/03/01
SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Chemical Properties,Usage,Production
Description
SA4503 (165377-44-6) is a potent and selective sigma 1 agonist (σ1 IC50?= 17.4 nM, σ2 IC50?= 1784 nM).1?It has been investigated as a cognition enhancer2,3, antidepressant4,5, anti-addiction agent6, and neuroprotectant7-10.
Uses
SA 4503 Dihydrochloride is a novel and selective σ1 receptor agonist.
Biochem/physiol Actions
SA4503 is a high affinity, orally active non-opioid intracellular receptor sigma-1 (σ1R) selective agonist (IC50 = 17.4 nM against 200 nM (+)-pentazocine for binding σ1R), exhibiting ~100-fold less affinity for the sigma 2 receptor subtype (σ2R) and little or no affinity toward 36 other receptors, ion channels and second messenger systems. Oral administration is reported to elicit cerebral acetylcholine (ACh) release in rat frontal cortex and hippocampus (5-20 mg/kg p.o.) and reduce immobility time in a mouse forced swimming test (Immobility time = 214.8 s without vs. 111.6 s with 1.0 mg/kg oral dosage).
storage
Desiccate at RT
References
1) Matsuno?et al.?(1996),?Binding properties of SA4503, a novel and selective sigma 1 receptor agonist; Eur. J. Pharmacol.?306?271 2) Matsuno?et al.?(1997),?SA4503, a novel cognition enhancer with sigma 1 agonistic properties; Behav. Brain Res.?83?221 3) Niitsu?et al.?(2012),?Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases; Curr. Pharm. Des.?18?875 4) Skuza and Rogoz?et al.?(2002),?A potential antidepressant activity of SA4503, a selective sigma 1 receptor agonist; Behav. Pharmacol.?13 537 5) Lucas?et al.?(2008),?Further evidence for an antidepressant potential of the selective sigma1 agonist SA4503: electrophysiological, morphological and behavioral studies; Int. J. Neuropsychopharmacol.?11?485 6) Mori?et al.?(2014),?Inhibitory effects of SA4503 on the rewarding effects of abused drugs; Addict. Biol.?19?362 7) Nakazawa?et al. (1998),?Activation of sigma1 receptor subtype leads to neuroprotection in the rat primary neuronal cultures; Neurochem. Int.?32?337 8) Ruscher?et al.?(2011),?The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke; Brain?134(Pt.3)?732 9) Ruscher?et al.?(2012),?Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride on inflammation after stroke; PLoS One.?7?e45118 10) Yamashita?et al.?(2015),?Neuroprotective effects of cutamesine, a ligand of the sigma-1 receptor chaperone, against noise-induced hearing loss; Int. J. Neurosci. Res.?93?788
SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE manufacturers
- Product
- SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE 165377-44-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09