2-CHLORO-3-(PIPERAZINYL)PYRAZINE

Product Name: 2-CHLORO-3-(PIPERAZINYL)PYRAZINE
CAS No.: 85386-99-8
Chemical Name: 2-CHLORO-3-(PIPERAZINYL)PYRAZINE
Synonyms: 2-Chloro-3-(piperazin-1-yl);2-CHLORO-3-(PIPERAZINYL)PYRAZINE;2-CHLORO-3-(1-PIPERAZINYL)PYRAZINE;Pyrazine, 2-chloro-3-(1-piperazinyl)-
CBNumber: CB91012005
Molecular Formula: C8H11ClN4
Formula Weight: 198.65
MOL File: 85386-99-8.mol

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2-CHLORO-3-(PIPERAZINYL)PYRAZINE Property

Boiling point:: 342.7±42.0 °C(Predicted)
Density: 1.272±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 8.11±0.10(Predicted)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C350880
Product name: 2-Chloro-3-(1-piperazinyl)pyrazine
Packaging: 25mg
Price: $60
Updated: 2021/12/16

TRC

Product number: C350880
Product name: 2-Chloro-3-(1-piperazinyl)pyrazine
Packaging: 50mg
Price: $100
Updated: 2021/12/16

TRC

Product number: C350880
Product name: 2-Chloro-3-(1-piperazinyl)pyrazine
Packaging: 100mg
Price: $155
Updated: 2021/12/16

Apolloscientific

Product number: OR911909
Product name: 2-Chloro-3-(1-piperazinyl)pyrazine
Purity: 95%
Packaging: 250mg
Price: $225
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC123979
Product name: 2-Chloro-3-piperazin-1-ylpyrazine
Packaging: 500mg
Price: $250
Updated: 2021/12/16

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2-CHLORO-3-(PIPERAZINYL)PYRAZINE Chemical Properties,Usage,Production

Synthesis

313654-83-0

85386-99-8

The general procedure for the synthesis of 2-chloro-3-piperazinopyrazine from tert-butyl 4-(3-chloropyrazin-2-yl)piperazine-1-carboxylate was as follows: tert-butyl 3'-chloro-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylate (10 g, 33.4 mmol, 1 eq.) was dissolved in 1,4-dioxane (160 mL), and 4 M hydrochloric acid in 1,4- dioxane solution (80 mL, 0.3 mol, 10 eq.). The reaction mixture was stirred overnight at room temperature under nitrogen protection. Upon completion of the reaction, the reaction solution was diluted with dichloromethane (600 mL) and subsequently alkalized with 50% aqueous sodium hydroxide. The organic and aqueous layers were separated after addition of water (100 mL). The aqueous layer was extracted twice with dichloromethane (200 mL). All organic extracts were combined, washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered and concentrated to give 3'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bis(pyrazinyl) product as a viscous oil, which solidified on standing (6.39 g, 96% yield). Mass spectrum (electrospray ionization): m/z = 199.1, 201.1 [M + H]+.

References

[1] Patent: WO2009/29439, 2009, A1. Location in patent: Page/Page column 14
[2] Patent: WO2008/141020, 2008, A1. Location in patent: Page/Page column 64
[3] Patent: WO2009/48765, 2009, A1. Location in patent: Page/Page column 10
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 11, p. 5467 - 5482
[5] Patent: WO2017/21879, 2017, A1. Location in patent: Page/Page column 114-115

2-CHLORO-3-(PIPERAZINYL)PYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-3-(PIPERAZINYL)PYRAZINE Suppliers

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85386-99-8, 2-CHLORO-3-(PIPERAZINYL)PYRAZINERelated Search:

2-Chloro-3-(piperazin-1-yl)

2-CHLORO-3-(PIPERAZINYL)PYRAZINE

2-CHLORO-3-(1-PIPERAZINYL)PYRAZINE

Pyrazine, 2-chloro-3-(1-piperazinyl)-

85386-99-8