ChemicalBook > CAS DataBase List > Ethanone,1-(4-pyrimidinyl)-

Ethanone,1-(4-pyrimidinyl)-

Product Name: Ethanone,1-(4-pyrimidinyl)-
CAS No.: 39870-05-8
Chemical Name: Ethanone,1-(4-pyrimidinyl)-
Synonyms: 1-(Pyrimidin-4-yl)ethanone;1-(pyriMidin-4-yl)ethan-1-one;4-Acetylpyrimidine;1-(Pyrimidin-4-yl);Methyl 4-pyrimidyl ketone;1-(4-Pyrimidinyl)ethanone;Methyl 4-pyriMidinyl ketone;4-Pyrimidinyl methyl ketone;Ethanone,1-(4-pyrimidinyl)-;Ethanone, 1-(4-pyrimidinyl)- (9CI)
CBNumber: CB91012434
Molecular Formula: C6H6N2O
Formula Weight: 122.12
MOL File: 39870-05-8.mol

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Ethanone,1-(4-pyrimidinyl)- Property

Melting point:: 67 °C
Boiling point:: 70 °C(Press: 3 Torr)
Density: 1.136±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -0.39±0.10(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C6H6N2O/c1-5(9)6-2-3-7-4-8-6/h2-4H,1H3
InChIKey: UZKADDSUUBRMKO-UHFFFAOYSA-N
SMILES: C(=O)(C1C=CN=CN=1)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: P997535
Product name: 1-(Pyrimidin-4-yl)ethanone
Packaging: 500mg
Price: $350
Updated: 2021/12/16

Matrix Scientific

Product number: 119223
Product name: 1-(Pyrimidin-4-yl)ethanone
Purity: 95+%
Packaging: 250mg
Price: $378
Updated: 2021/12/16

AK Scientific

Product number: W6021
Product name: 1-(Pyrimidin-4-yl)ethanone
Packaging: 1g
Price: $384
Updated: 2021/12/16

AK Scientific

Product number: W6021
Product name: 1-(Pyrimidin-4-yl)ethanone
Packaging: 5g
Price: $1051
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0069456
Product name: ETHANONE, 1-(4-PYRIMIDINYL)-
Purity: 95.00%
Packaging: 1G
Price: $1152.11
Updated: 2021/12/16

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Ethanone,1-(4-pyrimidinyl)- Chemical Properties,Usage,Production

Synthesis

289-95-2

75-07-0

39870-05-8

Example 1: General procedure for the synthesis of 4-pyrimidine acetophenone from pyrimidine and acetaldehyde 1. dissolve pyrimidine (2.5 g, 31.2 mmol) and acetaldehyde (10.8 mL, 192 mmol) in dichloromethane (190 mL) at 0 °C with stirring and slowly add 3.4 M sulfuric acid (15.6 mL). 2. The reaction solution was cooled to -5°C and the following two solutions were added dropwise through two different dropping funnels simultaneously over a period of about 30 minutes: - 80% tert-butyl hydroperoxide in tert-butyl oxide/water solution (23.4 mL) - A solution of ferrous sulfate heptahydrate (52.2 g) dissolved in 100 mL of water. 3. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0 °C for 2.5 hours. 4. After completion of the reaction, the phases were separated and the aqueous phase was extracted with dichloromethane (2 x 150 mL). 5. The organic phases were combined and washed sequentially with 10% aqueous sodium iodide, 10% aqueous Na2S2O5 and brine, then dried with anhydrous Na2SO4. 6. The dried organic phase was concentrated and the yellow solid obtained was absorbed with petroleum ether and filtered. 7. After drying, 4-pyrimidine ethanone was obtained as a brown solid (0.87 g, 23% yield).

References

[1] Drug Metabolism and Disposition, 2011, vol. 39, # 12, p. 2355 - 2360
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 17, p. 3288 - 3296
[3] Patent: WO2005/14572, 2005, A1. Location in patent: Page/Page column 24

Ethanone,1-(4-pyrimidinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethanone,1-(4-pyrimidinyl)- manufacturers

Career Henan Chemical Co

Product: Ethanone,1-(4-pyrimidinyl)- 39870-05-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

39870-05-8, Ethanone,1-(4-pyrimidinyl)-Related Search:

Ethanone,1-(2,6-dimethyl-4-pyrimidinyl)- 4-Pyrimidinecarbonitrile,6-acetyl- 6,7-bis(1-aziridinyl)-5,8-quinazolinedione (2-amino-4-pyrimidinyl)(phenyl)methanone 2-BROMO-1-(7-[(4-METHYLPHENYL)SULFONYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)ETHANONE 6,7-bis(1-aziridinyl)-4-((3-(N,N-dimethylamino)propyl)amino)-5,8-quinazolinedione Ethanone,1-(2-methyl-4-pyrimidinyl)- Ethanone,1-(2-amino-4-pyrimidinyl)- Ethanone,1-(4-pyrimidinyl)- BIS-(2-METHYLSULFANYL-PYRIMIDIN-4-YL)-METHANONE Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI) Ethanone,1-(6-methyl-4-pyrimidinyl)-

Ethanone,1-(4-pyrimidinyl)-

Ethanone, 1-(4-pyrimidinyl)- (9CI)

4-Acetylpyrimidine

4-Pyrimidinyl methyl ketone

Methyl 4-pyrimidyl ketone

1-(Pyrimidin-4-yl)

1-(Pyrimidin-4-yl)ethanone

1-(pyriMidin-4-yl)ethan-1-one

Methyl 4-pyriMidinyl ketone

1-(4-Pyrimidinyl)ethanone

39870-05-8

PYRIMIDINE

ACETYLGROUP