N-(4-METHOXYBENZYL)UREA

N-(4-METHOXYBENZYL)UREA Property

Melting point:

160-162°

Boiling point:

327.9±34.0 °C(Predicted)

Density 

1.156±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

13.63±0.46(Predicted)

Appearance

White to off-white Solid

Safety

HazardClass 

IRRITANT

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

N-(4-METHOXYBENZYL)UREA Chemical Properties,Usage,Production

Synthesis

GENERAL METHODS: N-(4-methoxybenzyl)cyanamide (1.0 mmol), glyoxime (2.0 mmol), cerium oxide nanoparticles (5.0 mol%) and anhydrous ethanol (5 mL) were sequentially added to a 25 mL round-bottomed flask equipped with a magnetic stirrer. The reaction mixture was heated to reflux under nitrogen protection with continuous stirring for 2 hours. After completion of the reaction, it was cooled to room temperature, filtered to remove the solid catalyst, and the filter cake was washed with anhydrous ethanol. The filtrates were combined and concentrated under reduced pressure to remove the solvent. The recovered catalyst was washed with dichloromethane and dried for 2 h. The catalyst was reused. The crude product was purified by column chromatography. All the compounds obtained from the isolation were characterized by melting point determination, infrared spectroscopy, NMR hydrogen spectroscopy, NMR carbon spectroscopy and elemental analysis. The physical data (melting point, IR spectra, NMR spectra) of the known compounds are in agreement with literature reports.

References

[1] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 2, p. 716 - 718
[2] Journal of Chemical Research, 2013, vol. 37, # 10, p. 623 - 625