ChemicalBook > CAS DataBase List > 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester

4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester

Product Name
4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester
CAS No.
24190-77-0
Chemical Name
4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester
Synonyms
Prucalopride Impurity 36;Prucalopride Impurity 61;4-Acetylamino-5-Chloro-2-;Methyl 4-acetamido-5-chlorosalicylate;4-acetylamino-5-chloro-2-methoxybenzoate;4-acetylaMino-5-chloro-2-hydroxybenzoate;Methyl 5-chloro-4-acetaMido-2-hydroxybenzoate;Methyl 2-hydroxy-4-acetamido-5-chlorobenzoate;methyl 4-acetamido-2-hydroxy-5-chlorobenzoate;Methyl 4-acetylaMino-5-chloro-2-hdroxybenzoate
CBNumber
CB91013815
Molecular Formula
C10H10ClNO4
Formula Weight
243.64
MOL File
24190-77-0.mol
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4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester Property

Melting point:
145-146℃
Boiling point:
428.2±45.0 °C(Predicted)
Density 
1.426
storage temp. 
Sealed in dry,Room Temperature
pka
8.87±0.23(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M331213
Product name
Methyl4-Acetamido-5-chloro-2-hydroxybenzoate
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
M331213
Product name
Methyl4-Acetamido-5-chloro-2-hydroxybenzoate
Packaging
500mg
Price
$110
Updated
2021/12/16
AK Scientific
Product number
W4773
Product name
4-Acetylamino-5-Chloro-2-HydroxybenzoicacidMethylEster
Packaging
10g
Price
$207
Updated
2021/12/16
Matrix Scientific
Product number
073939
Product name
Methyl 4-acetylamino-5-chloro-2-hydroxybenzoate
Purity
95+%
Packaging
1g
Price
$231
Updated
2021/12/16
Matrix Scientific
Product number
073939
Product name
Methyl 4-acetylamino-5-chloro-2-hydroxybenzoate
Purity
95+%
Packaging
5g
Price
$639
Updated
2021/12/16
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4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester Chemical Properties,Usage,Production

Synthesis

4093-28-1

24190-77-0

Methyl 4-acetamido-2-hydroxybenzoate (61.4 g, 294.0 mmol) was dissolved with stirring in dichloroethane (1.2 L) followed by the addition of N-chlorosuccinimide (58.8 g, 441 mmol). The reaction mixture was heated to reflux for 3 hours. Upon completion of the reaction, the volatile solvent was removed by distillation under reduced pressure. Water (1.0 liter) was added to the residue to precipitate the solid product, which was collected by filtration. The crude product was dissolved in a solvent mixture of methanol and dichloromethane (1:9 v/v) and washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford methyl 4-acetamido-5-chloro-2-hydroxybenzoate (67.7 g) in 94.6% yield. The structure of the product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (DMSO-d6): δ 10.49 (broad single peak, 1H), 9.47 (single peak, 1H), 7.75 (single peak, 1H), 7.72 (single peak, 1H), 3.85 (single peak, 3H), 2.16 (single peak, 3H); mass spectrometry analysis showed the molecular ion peaks (m/z) to be 244 and 246 (M+H)+.

References

[1] Patent: WO2013/42135, 2013, A1. Location in patent: Page/Page column 11
[2] Patent: US2014/187581, 2014, A1. Location in patent: Paragraph 0098-0100
[3] Patent: WO2016/128990, 2016, A1. Location in patent: Page/Page column 26-27
[4] Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 22, p. 2657 - 2662
[5] Patent: CN107337658, 2017, A. Location in patent: Paragraph 0043; 0044

4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester manufacturers

Career Henan Chemical Co
Product
4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester 24190-77-0
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-21

24190-77-0, 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl EsterRelated Search:

Methyl 4-acetamido-5-chloro-2-methoxybenzoate 5-Chloro-2-hydroxybenzoic acid AURORA 5041 AURORA 4588 AURORA 4586 AURORA 5040 AURORA 4725 AURORA 4587 AURORA 5039 AURORA 3707 AURORA 4653 AURORA 4677 AURORA 4675 AURORA 4844 AURORA 4182 AURORA 4676 AURORA 4678 AURORA 22999

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  • 24190-77-0
  • 2419-77-0