ChemicalBook > CAS DataBase List > Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]-

Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]-

Product Name
Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]-
CAS No.
928712-10-1
Chemical Name
Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]-
Synonyms
HG106;2-Chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]acetamide;Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]-;2-Chloro-N-(2-(4-methoxyphenyl)-2H-benzo[d][1,2,3]triazol-5-yl)acetamide
CBNumber
CB910258755
Molecular Formula
C15H13ClN4O2
Formula Weight
316.74
MOL File
928712-10-1.mol
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Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]- Property

Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 21 mg/mL (66.30 mM);Ethanol: Insoluble
pka
10.89±0.43(Predicted)
form 
Solid
color 
Off-white to light yellow
Water Solubility 
Water: Insoluble
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]- Chemical Properties,Usage,Production

Uses

HG106 is an effective SLC7A11 inhibitor. HG106 mediates apoptosis by increasing oxidative stress and endoplasmic reticulum stress, and it has antitumor activity[1].

Biological Activity

HG106, a potent SLC7A11 inhibitor, leads to enhanced ROS generation, ER stress, and ultimately growth arrest specifically in KRAS-mutant lung adenocarcinoma (LUAD).

in vivo

HG106 (0-4 mg/kg, once a day, intraperitoneal injection, 26 days) inhibits tumor growth in A549 mouse transplant model[1].
HG106 (0-4 mg/kg, once a day, intraperitoneal injection, 20 days) inhibits tumor growth in mice in a xenograft model and induces apoptosis by triggering endoplasmic membrane stress[1].

Animal Model:A549 mouse transplant model[1]
Dosage:0, 1, 2, 4 mg/kg; daily; 26 days
Administration:Intraperitoneal injection (i.p.)
Result:Inhibited tumor growth and prolonged the inhibition time of tumor growth.
Animal Model:LUAD patient-derived xenograft (PDX) models harboring the G12V mutation in KRAS[1]
Dosage:0, 1, 2, 4 mg/kg; daily; 20 days
Administration:Intraperitoneal injection (i.p.)
Result:Inhibited tumor growth, increased ROS generation and TUNEL signal in patient-derived xenografts validated that HG106 triggered endoplasmic membrane stress-induced apoptosis in vivo.

References

[1] Hu K, et al. J Clin Invest. 2020 Apr 1;130(4):1752-1766.

Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]- Suppliers

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Shanghaizehan biopharma technology co., Ltd.
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928712-10-1, Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]-Related Search:


  • Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]-
  • HG106
  • 2-Chloro-N-(2-(4-methoxyphenyl)-2H-benzo[d][1,2,3]triazol-5-yl)acetamide
  • 2-Chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]acetamide
  • 928712-10-1