Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]-
- Product Name
- Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]-
- CAS No.
- 928712-10-1
- Chemical Name
- Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]-
- Synonyms
- HG106;2-Chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]acetamide;Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]-;2-Chloro-N-(2-(4-methoxyphenyl)-2H-benzo[d][1,2,3]triazol-5-yl)acetamide
- CBNumber
- CB910258755
- Molecular Formula
- C15H13ClN4O2
- Formula Weight
- 316.74
- MOL File
- 928712-10-1.mol
Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]- Property
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 21 mg/mL (66.30 mM);Ethanol: Insoluble
- pka
- 10.89±0.43(Predicted)
- form
- Solid
- color
- Off-white to light yellow
- Water Solubility
- Water: Insoluble
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]- Chemical Properties,Usage,Production
Uses
HG106 is an effective SLC7A11 inhibitor. HG106 mediates apoptosis by increasing oxidative stress and endoplasmic reticulum stress, and it has antitumor activity[1].
Biological Activity
HG106, a potent SLC7A11 inhibitor, leads to enhanced ROS generation, ER stress, and ultimately growth arrest specifically in KRAS-mutant lung adenocarcinoma (LUAD).
in vivo
HG106 (0-4 mg/kg, once a day, intraperitoneal injection, 26 days) inhibits tumor growth in A549 mouse transplant model[1].
HG106 (0-4 mg/kg, once a day, intraperitoneal injection, 20 days) inhibits tumor growth in mice in a xenograft model and induces apoptosis by triggering endoplasmic membrane stress[1].
| Animal Model: | A549 mouse transplant model[1] |
| Dosage: | 0, 1, 2, 4 mg/kg; daily; 26 days |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Inhibited tumor growth and prolonged the inhibition time of tumor growth. |
| Animal Model: | LUAD patient-derived xenograft (PDX) models harboring the G12V mutation in KRAS[1] |
| Dosage: | 0, 1, 2, 4 mg/kg; daily; 20 days |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Inhibited tumor growth, increased ROS generation and TUNEL signal in patient-derived xenografts validated that HG106 triggered endoplasmic membrane stress-induced apoptosis in vivo. |
References
[1] Hu K, et al. J Clin Invest. 2020 Apr 1;130(4):1752-1766.
Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Acetamide, 2-chloro-N-[2-(4-methoxyphenyl)-2H-benzotriazol-5-yl]- Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
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