ChemicalBook > CAS DataBase List > Edratide
Edratide
- Product Name
- Edratide
- CAS No.
- 433922-67-9
- Chemical Name
- Edratide
- Synonyms
- Edratide;EDRATIDUM;Edratide [inn];Unii-38plp07bkc;Edratide Acetate;Glycyl-L-tyrosyl-L-tyrosyl-L-tryptophyl-L-seryl-L-tryptophyl-L-isoleucyl-L-arginyl-L-glutaminyl-L-prolyl-L-prolylglycyl-L-lysylglycyl-L-glutamyl-L-glutamyl-L-tryptophyl-L-isoleucylglycine;Glycine, glycyl-L-tyrosyl-L-tyrosyl-L-tryptophyl-L-seryl-L-tryptophyl-L-isoleucyl-L-arginyl-L-glutaminyl-L-prolyl-L-prolylglycyl-L-lysylglycyl-L-α-glutamyl-L-α-glutamyl-L-tryptophyl-L-isoleucyl-
- CBNumber
- CB91027205
- Molecular Formula
- C111H149N27O28
- Formula Weight
- 2309.53
- MOL File
- 433922-67-9.mol
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Edratide Property
- Density
- 1.50±0.1 g/cm3(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Gly-Tyr-Tyr-Trp-Ser-Trp-Ile-Arg-Gln-Pro-Pro-Gly-Lys-Gly-Glu-Glu-Trp-Ile-Gly
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- API0009369
- Product name
- TV-4710
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.28
- Updated
- 2021/12/16
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Edratide Chemical Properties,Usage,Production
Uses
Treatment of systemic lupus erythematosus.
in vivo
Edratide (20-50 μg; s.c.; once a week for 10 weeks) exerts beneficial effects on SLE is through regulation of gene expression[2].
Edratide (50 μg/mouse; s.c.; 10 weekly) reduces the rates of apoptosis and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL in SLE mouse[3].
| Animal Model: | 6-7 months female mice (with established SLE)[2] |
| Dosage: | 20-50 μg |
| Administration: | Subcutaneously injection; once a week for 10 weeks |
| Result: | Up-regulated the RNA transcripts of Tnfsf4, Il5ra, Zbtb20, Nid1, down-regulated the transcripts of Tfpi and S100a8. |
| Animal Model: | 7-8 months SLE-afflicted BWF1 female mice[3] |
| Dosage: | 50 μg/mouse |
| Administration: | S.c.; 10 weekly |
| Result: | Reduced apoptosis, down-regulated caspase-8 and caspase-3, and up-regulated Bcl-xL. |
Edratide Preparation Products And Raw materials
Raw materials
Preparation Products
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