Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI)

Product Name: Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI)
CAS No.: 185619-66-3
Chemical Name: Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI)
Synonyms: N-Boc-3-ethynylaniline;tert-butyl 3-ethynylphenylcarbamate;tert-butyl N-(3-ethynylphenyl)carbamate;tert-Butyl (3-ethynylphenyl)carbamate - [B56910];Carbamic acid, N-(3-ethynylphenyl)-, 1,1-dimethylethyl ester;Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI)
CBNumber: CB91054814
Molecular Formula: C13H15NO2
Formula Weight: 217.26
MOL File: 185619-66-3.mol

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Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI) Property

storage temp.: 2-8°C
form: solid
color: Grey

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Synthonix

Product number: B56910
Product name: tert-Butyl(3-ethynylphenyl)carbamate
Purity: 97%
Packaging: 250mg
Price: $40
Updated: 2021/12/16

Synthonix

Product number: B56910
Product name: tert-Butyl(3-ethynylphenyl)carbamate
Purity: 97%
Packaging: 1g
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: 9710AA
Product name: tert-Butyl(3-ethynylphenyl)carbamate
Packaging: 1g
Price: $277
Updated: 2021/12/16

Synthonix

Product number: B56910
Product name: tert-Butyl(3-ethynylphenyl)carbamate
Purity: 97%
Packaging: 5g
Price: $390
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0097306
Product name: TERT-BUTYL 3-ETHYNYLPHENYLCARBAMATE
Purity: 95.00%
Packaging: 5MG
Price: $499.55
Updated: 2021/12/16

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Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Usage,Production

Synthesis

24424-99-5

54060-30-9

185619-66-3

Step a) Synthesis of tert-butyl (3-ethynylphenyl)carbamate: 3-ethynylaniline (25.0 g, 213 mmol) and di-tert-butyl dicarbonate (93.1 g, 427 mmol) were dissolved in THF (427 mL) and the reaction was heated at 70 °C overnight. After the reaction was completed, it was cooled to room temperature, 3-dimethylamino-1-propylamine (32.1 g, 320 mmol) was added and stirred at room temperature for 1 hour. The reaction mixture was concentrated, extracted with ether and washed sequentially with 1N HCl, saturated saline, saturated sodium bicarbonate solution and saturated saline. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product tert-butyl (3-alkynylphenyl)carbamate (45.0 g, 97% yield). The structure of the product was confirmed by NMR and mass spectrometry.

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 20, p. 4232 - 4235
[2] Patent: US2009/48320, 2009, A1. Location in patent: Page/Page column 39-40
[3] Patent: WO2005/60970, 2005, A1. Location in patent: Page/Page column 148
[4] Patent: WO2017/210471, 2017, A1. Location in patent: Paragraph 001146; 001147
[5] Patent: WO2008/61236, 2008, A2. Location in patent: Page/Page column 71

Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI) Suppliers

China 28 Europe 1 India 1 United Kingdom 1 United States 3 Global 34

Shanghai Sunway Pharmaceutical Technology Co., Ltd

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View Lastest Price from Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI) manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: TERT-BUTYL (3-ETHYNYLPHENYL)CARBAMATE 185619-66-3
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-13

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: tert-butyl N-(3-ethynylphenyl)carbamate 185619-66-3
Price: US $100.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-14

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: TERT-BUTYL (3-ETHYNYLPHENYL)CARBAMATE 185619-66-3
Price: US $100.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-15

185619-66-3, Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI)Related Search:

Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI)

tert-butyl 3-ethynylphenylcarbamate

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Carbamic acid, N-(3-ethynylphenyl)-, 1,1-dimethylethyl ester

tert-butyl N-(3-ethynylphenyl)carbamate

tert-Butyl (3-ethynylphenyl)carbamate - [B56910]

185619-66-3

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