Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI)
- Product Name
- Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI)
- CAS No.
- 333743-54-7
- Chemical Name
- Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI)
- Synonyms
- (R)-tert-butyl 2-aminopropylcarbamate;-tert-Butyl (2-aminopropyl);(R)-N1-Boc-1,2-propanediamine;R-1-n-boc-propane-1,2-diaMine;R-1-N-BOC-propane-1,2-diamine-HCl;tert-Butyl ((R)-2-aminopropyl)carbamate;tert-butyl N-[(2R)-2-aMinopropyl]carbaMate;(R)-1-N-Boc-Propane-1,2-diaMine hydrochloride;((R)-2-Aminopropyl)carbamic acid tert-butyl ester;[(R)-2-Amino-1-propyl]carbamic acid tert-butyl ester
- CBNumber
- CB91056227
- Molecular Formula
- C8H18N2O2
- Formula Weight
- 174.24
- MOL File
- 333743-54-7.mol
Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI) Property
- Boiling point:
- 264℃
- Density
- 0.984
- Flash point:
- 113℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 12.51±0.46(Predicted)
- Appearance
- Colorless to off-white Liquid
- optical activity
- Consistent with structure
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FB156173
- Product name
- (R)-1-N-Boc-Propane-1,2-diamine hydrochloride
- Packaging
- 100mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- W5509
- Product name
- (R)-1-N-Boc-Propane-1,2-diaminehydrochloride
- Packaging
- 100mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- FB156173
- Product name
- (R)-1-N-Boc-Propane-1,2-diamine hydrochloride
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- FB156173
- Product name
- (R)-1-N-Boc-Propane-1,2-diamine hydrochloride
- Packaging
- 500mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- W5509
- Product name
- (R)-1-N-Boc-Propane-1,2-diaminehydrochloride
- Packaging
- 1g
- Price
- $351
- Updated
- 2021/12/16
Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Usage,Production
Synthesis
6627-89-0
19777-66-3
333743-54-7
NaOH (8.82 g, 0.2205 mol) was dissolved in 96% ethanol (150 mL) under vigorous stirring, followed by the addition of (S)-(-)-diaminopropane dihydrochloride (16.36 g, 0.11 mol). After 2 hours of reaction, the resulting white precipitate was removed by filtration. To the filtrate was added tert-butyl phenyl carbonate (39.37 g, 0.203 mol) and the mixture was refluxed for 24 hours. After completion of the reaction, the solvent was removed by vacuum concentration to give a colorless oil. To this oily substance, water (175 mL) was added and the pH was adjusted to 3 with 2M H2SO4. The aqueous phase was washed with CH2Cl2 (3 x 200 mL) and then the pH was adjusted to 12 with 2M NaOH. Subsequently, the aqueous phase was extracted with CH2Cl2 (4 x 200 mL), and the organic phases were combined, dried over Na2SO4, and concentrated to give (R)-(2-aminopropyl)amino tert-butyl formate as a colorless oil (9.58 g, 50% yield). The product was characterized by 1H NMR (300 MHz, CDCl3), 13C NMR (126 MHz, CDCl3) and MS (FAB), and the correct structure was confirmed.
References
[1] Tetrahedron, 2015, vol. 71, # 7, p. 1109 - 1116
[2] Patent: US2009/247519, 2009, A1. Location in patent: Page/Page column 134
Carbamic acid, [(2R)-2-aminopropyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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