Pyrimidine, 4-amino-6-cyclopropyl- (7CI,8CI)

Product Name: Pyrimidine, 4-amino-6-cyclopropyl- (7CI,8CI)
CAS No.: 7043-08-5
Chemical Name: Pyrimidine, 4-amino-6-cyclopropyl- (7CI,8CI)
Synonyms: 6-cyclopropyl-4-Pyrimidinamine;6-CyclopropylpyriMidin-4-aMine;4-Pyrimidinamine, 6-cyclopropyl-;4-Amino-6-(cyclopropyl)pyrimidine;Pyrimidine, 4-amino-6-cyclopropyl- (7CI,8CI)
CBNumber: CB91057749
Molecular Formula: C7H9N3
Formula Weight: 135.17
MOL File: 7043-08-5.mol

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Pyrimidine, 4-amino-6-cyclopropyl- (7CI,8CI) Property

Melting point:: 151-153 °C
Boiling point:: 305.4±30.0 °C(Predicted)
Density: 1.273±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 5.72±0.10(Predicted)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: 6910DF
Product name: 6-Cyclopropylpyrimidin-4-amine
Packaging: 250mg
Price: $307
Updated: 2021/12/16

Matrix Scientific

Product number: 101938
Product name: 6-Cyclopropylpyrimidin-4-amine
Purity: 95%
Packaging: 250mg
Price: $449
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-0M
Product name: 6-Cyclopropylpyrimidin-4-amine
Packaging: 250mg
Price: $557
Updated: 2021/12/16

Matrix Scientific

Product number: 101938
Product name: 6-Cyclopropylpyrimidin-4-amine
Purity: 95%
Packaging: 500mg
Price: $721
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-0M
Product name: 6-Cyclopropylpyrimidin-4-amine
Packaging: 1g
Price: $1056
Updated: 2021/12/16

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Pyrimidine, 4-amino-6-cyclopropyl- (7CI,8CI) Chemical Properties,Usage,Production

Synthesis

1378040-20-0

1378040-19-7

7043-08-5

Step 2: A mixture of tert-butyl 6-cyclopropylpyrimidin-4-ylcarbamate (256 mg, 0.764 mmol) and tert-butyl 6-cyclopropylpyrimidin-4-ylcarbamate (10 mg, 0.043 mmol) was dissolved in a dioxane solution of 4N HCl (3.0 mL, 12 mmol) and heated for 3 hr at 55 °C. Subsequently, additional dioxane solution of 4N HCl (1.0 mL, 4 mmol) was added and the reaction mixture was warmed up to 70°C to continue heating for 1.5 hours, followed by stirring at room temperature overnight. Upon completion of the reaction, the mixture was partitioned between saturated aqueous sodium bicarbonate solution and ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by rapid chromatography on silica gel (eluent: dichloromethane solution of 2-5% methanol) to give 6-cyclopropylpyrimidin-4-amine (84 mg, 78% yield). The product was characterized by NMR (400 MHz, methanol-d4): δ 8.17 (d, J = 1.1 Hz, 1H), 6.36 (d, J = 1.2 Hz, 1H), 4.61 (br s, 2H), 1.90-1.81 (m, 1H), 1.03-0.94 (m, 4H).

References

[1] Patent: WO2012/66061, 2012, A1. Location in patent: Page/Page column 178

Pyrimidine, 4-amino-6-cyclopropyl- (7CI,8CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyrimidine, 4-amino-6-cyclopropyl- (7CI,8CI) Suppliers

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7043-08-5, Pyrimidine, 4-amino-6-cyclopropyl- (7CI,8CI)Related Search:

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