MMP-13 SUBSTRATE, FLUOROGENIC
- Product Name
- MMP-13 SUBSTRATE, FLUOROGENIC
- Chemical Name
- MMP-13 SUBSTRATE, FLUOROGENIC
- Synonyms
- 390 MMP FRET SUBSTRATE IV;MMP-13 SUBSTRATE, FLUOROGENIC;MCA-P-CHA-G-NVA-HA-DAP(DNP)-NH2;MCA-PRO-CHA-GLY-NVA-HIS-ALA-DPA-NH2;COLLAGENASE-3 SUBSTRATE, FLUOROGENIC;MCA-PRO-CHA-GLY-NVA-HIS-ALA-DAP(DNP)-NH2
- CBNumber
- CB9106110
- Molecular Formula
- C51H65N13O15
- Formula Weight
- 1100.14
- MOL File
- Mol file
MMP-13 SUBSTRATE, FLUOROGENIC Property
- storage temp.
- -20°C
- solubility
- DMSO: 5mg/mL
- form
- lyophilized solid
- color
- yellow
N-Bromosuccinimide Price
- Product number
- 444235-M
- Product name
- MMP-13 Substrate, Fluorogenic
- Purity
- A quenched fluorescence substrate for MMP-13 (collagenase-3; k<sub>cat</sub>/Km</sub> = 1.09 x 10⁶ M⁻¹s⁻¹).
- Packaging
- 1 unit
- Price
- $271
- Updated
- 2025/07/31
MMP-13 SUBSTRATE, FLUOROGENIC Chemical Properties,Usage,Production
Description
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. 7-methoxycoumarin-4-acetyl (Mca) is released by cleavage of Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2, of which the fluorescence can be used to quantify MMP-1, MMP-3 and MMP-26 activity.
Uses
Matrix metalloproteinases (MMP) are a family of zinc-dependent endopeptidases th at degrade matrix proteins. MMPs include collagenases, gelatinases, matrilysins, enamelysins, metalloelastases, stromelysins and other structural protein and receptor lysins. The activity of these enzymes is selectively inhibited or measured by appropriately labeled peptides. MCA-Pro-Cha-Gly-Nva-His-Ala-DNP-DPA-NH2 is used as a fluorogenic substrate for matrix metalloprotein-13 (collagenase-3, MMP-13).
Biological Activity
Primary Target
A quenched fluorescence substrate for MMP-13 (collagenase-3)', 'kcat/Km = 1.09 x 106 M-¹ sec-¹ for MMP-13 (collagenase-3)
Sequene
Mca-Pro-Cha-Gly-Nva-His-Ala-Dap(Dnp)-NH2
MMP-13 SUBSTRATE, FLUOROGENIC Preparation Products And Raw materials
Raw materials
Preparation Products
MMP-13 SUBSTRATE, FLUOROGENIC Suppliers
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