Benzenesulfonyl chloride, 5-fluoro-2-methoxy- (9CI)
- Product Name
- Benzenesulfonyl chloride, 5-fluoro-2-methoxy- (9CI)
- CAS No.
- 67475-56-3
- Chemical Name
- Benzenesulfonyl chloride, 5-fluoro-2-methoxy- (9CI)
- Synonyms
- 5-fluoro-2-Methoxy- (9CI);2-(Chlorosulphonyl)-4-fluoroanisole;2-Methoxy-5-fluorobenzenesulfonylchloride;5-fluoro-2-Methoxybenzene-1-sulfonyl chloride;Benzenesulfonyl chloride, 5-fluoro-2-methoxy-;Benzenesulonyl chloride, 5-fluoro-2-methoxy-(9CI);5-Fluoro-2-methoxybenzene-1-sulfonyl chloride 95%;Benzenesulfonyl chloride, 5-fluoro-2-methoxy- (9CI);Benzenesulfonyl chloride, 5-fluoro-2-methoxy- (9CI) ISO 9001：2015 REACH
- CBNumber
- CB91061326
- Molecular Formula
- C7H6ClFO3S
- Formula Weight
- 224.64
- MOL File
- 67475-56-3.mol
Benzenesulfonyl chloride, 5-fluoro-2-methoxy- (9CI) Property
- Boiling point:
- 309.8±27.0 °C(Predicted)
- Density
- 1.455±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystals
- color
- Off white
- InChI
- InChI=1S/C7H6ClFO3S/c1-12-6-3-2-5(9)4-7(6)13(8,10)11/h2-4H,1H3
- InChIKey
- LUEBMKPHZDSPFH-UHFFFAOYSA-N
- SMILES
- C1(S(Cl)(=O)=O)=CC(F)=CC=C1OC
Safety
- RIDADR
- UN3261
- HazardClass
- IRRITANT
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H290May be corrosive to metals
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P234Keep only in original container.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P390Absorb spillage to prevent material damage.
P405Store locked up.
P406Store in corrosive resistant/… container with a resistant inner liner.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F597460
- Product name
- 5-Fluoro-2-methoxybenzenesulfonylchloride
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- F597460
- Product name
- 5-Fluoro-2-methoxybenzenesulfonylchloride
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Z5020
- Product name
- 5-Fluoro-2-methoxybenzene-1-sulfonylchloride
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- HCH0035978
- Product name
- 5-FLUORO-2-METHOXYBENZENESULFONYL CHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $826.98
- Updated
- 2021/12/16
- Product number
- HCH0035978
- Product name
- 5-FLUORO-2-METHOXYBENZENESULFONYL CHLORIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1367.52
- Updated
- 2021/12/16
Benzenesulfonyl chloride, 5-fluoro-2-methoxy- (9CI) Chemical Properties,Usage,Production
Uses
5-Fluoro-2-methoxybenzenesulfonyl chloride
Synthesis
459-60-9
67475-56-3
The general procedure for the synthesis of 5-fluoro-2-methoxybenzenesulfonyl chloride from 4-fluoroanisole was as follows: 1-fluoro-4-methoxybenzene (10.0 g, 0.079 mol) was slowly added dropwise to sulfuryl chloride (31.4 ml, 0.474 mol) at 0 °C. The reaction mixture was stirred at room temperature for 6 h, followed by slow dropwise addition to ice water for quenching. The mixture was extracted three times with dichloromethane (CH2Cl2). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 5-fluoro-2-methoxybenzenesulfonyl chloride (15.0 g, 84.6% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 3.74 (s, 3H), 6.97 (dd, J = 4.3, 8.9 Hz, 1H), 7.13 (dt, J = 3.4, 8.6 Hz, 1H), 7.41 (dd, J = 3.3, 8.8 Hz, 1H).
References
[1] Patent: WO2010/31, 2010, A1. Location in patent: Page/Page column 86
[2] Tetrahedron, 2016, vol. 72, # 47, p. 7570 - 7578
[3] Patent: WO2013/126608, 2013, A1. Location in patent: Paragraph 00812
[4] Patent: WO2005/18529, 2005, A2. Location in patent: Page/Page column 54
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 8, p. 1735 - 1746
Benzenesulfonyl chloride, 5-fluoro-2-methoxy- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Benzenesulfonyl chloride, 5-fluoro-2-methoxy- (9CI) Suppliers
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