Benzene, 4-bromo-2-ethyl-1-fluoro- (9CI)

Benzene, 4-bromo-2-ethyl-1-fluoro- (9CI) Property

Boiling point:

201.0±20.0 °C(Predicted)

Density 

1.423±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Methanol (Slightly)

form 

Oil

color 

Colourless

Safety

HS Code 

2903998090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Benzene, 4-bromo-2-ethyl-1-fluoro- (9CI) Chemical Properties,Usage,Production

Synthesis

The general procedure for the synthesis of 4-bromo-2-ethyl-1-fluorobenzene (9ci) from 4-bromo-2-vinyl-1-fluorobenzene was as follows: the yellow oily substance (2.8 g, 10 mmol) obtained in step A was dissolved in ethyl acetate (200 mL). 10% palladium-carbon catalyst (250 mg) was added to the solution and the hydrogenation reaction was carried out at atmospheric pressure (1 atm) until thin layer chromatography (TLC) monitoring showed that the reaction was complete. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the target product 4-bromo-2-ethyl-1-fluorobenzene (9ci) as an oil in a yield of 2.4 g in 87%.

References

[1] Patent: US2004/6058, 2004, A1. Location in patent: Page/Page column 30
[2] Patent: WO2017/158151, 2017, A1. Location in patent: Page/Page column 101
[3] Patent: US2010/227894, 2010, A1. Location in patent: Page/Page column 74