2-AMINO-5-(TRIFLUOROMETHOXY)BENZONITRILE
- Product Name
- 2-AMINO-5-(TRIFLUOROMETHOXY)BENZONITRILE
- CAS No.
- 549488-77-9
- Chemical Name
- 2-AMINO-5-(TRIFLUOROMETHOXY)BENZONITRILE
- Synonyms
- 2-AMINO-5-(TRIFLUOROMETHOXY)BENZONITRILE;Benzonitrile, 2-amino-5-(trifluoromethoxy)-;2-Cyano-4-(trifluoromethoxy)aniline, 5-(Trifluoromethoxy)anthranilonitrile
- CBNumber
- CB91091057
- Molecular Formula
- C8H5F3N2O
- Formula Weight
- 202.13
- MOL File
- 549488-77-9.mol
2-AMINO-5-(TRIFLUOROMETHOXY)BENZONITRILE Property
- Boiling point:
- 252.6±40.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.96±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A633610
- Product name
- 2-Amino-5-(trifluoromethoxy)benzonitrile
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 1978AL
- Product name
- 2-Amino-5-(trifluoromethoxy)benzonitrile
- Packaging
- 1g
- Price
- $124
- Updated
- 2021/12/16
- Product number
- CS-0022506
- Product name
- 2-Amino-5-(trifluoromethoxy)benzonitrile
- Purity
- 99.96%
- Packaging
- 5g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 4637-3-W3
- Product name
- 2-Amino-5-(trifluoromethoxy)benzonitrile
- Packaging
- 1g
- Price
- $205
- Updated
- 2021/12/16
- Product number
- 1978AL
- Product name
- 2-Amino-5-(trifluoromethoxy)benzonitrile
- Packaging
- 5g
- Price
- $284
- Updated
- 2021/12/16
2-AMINO-5-(TRIFLUOROMETHOXY)BENZONITRILE Chemical Properties,Usage,Production
Synthesis
544-92-3
175278-17-8
549488-77-9
To a solution of 2-bromo-4-(trifluoromethoxy)aniline (15.1 g, 60.0 mmol) in N-methylpyrrolidone (100 mL) was added cuprous cyanide (10.6 g, 118 mmol), and the reaction mixture was stirred at 0 °C for 6.5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and poured into a mixture of ice water (300 mL) and ammonia (350 mL). The resulting brown precipitate was collected by filtration, washed with water (150 mL), and then the precipitate was dissolved in dichloromethane (350 mL). Insoluble material was removed by filtration and the filtrate was washed with brine (100 mL) and dried over anhydrous sodium sulfate. Purification by silica gel column chromatography (eluent:heptane/ethyl acetate=95:5 to 25:75) afforded 2-amino-5-trifluoromethoxybenzonitrile (9.09 g, 76% yield) as a brown solid. Mass spectrum (MS): m/e = 405.1 [2M + H]+.
References
[1] Patent: US2006/79507, 2006, A1. Location in patent: Page/Page column 16
2-AMINO-5-(TRIFLUOROMETHOXY)BENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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