ChemicalBook > CAS DataBase List > CAPADENOSON

CAPADENOSON

Product Name: CAPADENOSON
CAS No.: 544417-40-5
Chemical Name: CAPADENOSON
Synonyms: CS-1666;BAY 68-4986;CAPADENOSON;Capadenoson, BAY 68-4986;Capadenoson, 10 mM in DMSO;Adenosine Receptor,P1 receptor,Inhibitor,inhibit,Capadenoson;2-Amino-6-[[[2-(4-chlorophenyl)-4-thiazolyl]methyl]thio]-4-[4-(2-hydroxyethoxy)phenyl]-3,5-pyridinedicarbonitrile;2-Amino-6-(((2-(4-chlorophenyl)thiazol-4-yl)methyl)thio)-4-(4-(2-hydroxyethoxy)phenyl)pyridine-3,5-dicarbonitrile;3,5-Pyridinedicarbonitrile, 2-amino-6-[[[2-(4-chlorophenyl)-4-thiazolyl]methyl]thio]-4-[4-(2-hydroxyethoxy)phenyl]-;2-amino-6-[[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile
CBNumber: CB91092261
Molecular Formula: C25H18ClN5O2S2
Formula Weight: 520.03
MOL File: 544417-40-5.mol

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CAPADENOSON Property

Boiling point:: 787.9±70.0 °C(Predicted)
Density: 1.51
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 13.98±0.10(Predicted)
color: Light yellow to yellow
InChIKey: CITWCLNVRIKQAF-UHFFFAOYSA-N
SMILES: C1(N)=NC(SCC2=CSC(C3=CC=C(Cl)C=C3)=N2)=C(C#N)C(C2=CC=C(OCCO)C=C2)=C1C#N

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

H370Causes damage to organs

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2852
Product name: Capadenoson
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $78.18
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2852
Product name: Capadenoson
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $268
Updated: 2025/07/31

Cayman Chemical

Product number: 28422
Product name: Capadenoson
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 28422
Product name: Capadenoson
Packaging: 10mg
Price: $380
Updated: 2024/03/01

Cayman Chemical

Product number: 28422
Product name: Capadenoson
Packaging: 5mg
Price: $216
Updated: 2024/03/01

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CAPADENOSON Chemical Properties,Usage,Production

Uses

Capadenoson is a selective agonist of adenosine-A1 receptor.

Biological Activity

Capadenoson (BAY 68-4986) is an adenosine receptor A1 (A1AR) partial agonist (GTPγS binding EC50/Emax = 0.1 nM/74% vs. 0.3 nM/100% with CCPA; human cortex membranes) th at exerts additional biased A2BAR agonism toward cAMP signal transduction (pEC50 = 8.94/cAMP, 6.20/Ca+2, 6.12/pERK, 5.03/IP1), while exhibiting weak A2A & A3 potency. Capadenoson offers cardioprotection efficacy in an ischemia-reperfusion injury r at model in vivo (25/28% infarct size reduction with 0.1/0.3 mg/kg iv.) without the risk of a full atrioventricular (AV) block (isolated perfused r at heart rate = 100% up to 10 nM, 90% at ≥10 μM) seen with the full A1 agonist CCPA.

in vivo

In the in vivo experiments, Wistar rats and SHR are pre-treated with Capadenoson at a concentration of 0.15 mg/kg for 5 days. On day 5, a stress test (physical restraint) is performed for 2 hours. The plasma concentration of Capadenoson measured 3 hours after drug intake remains constant in the 5 days prior to the restraint stress test and averaged 7.63 μg/L on day 4 and 5, respectively^[1].

target

adenosine A1 receptor

References

[1] Bott-Flügel L, et al. Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism. PLoS One. 2011 Mar 28;6(3):e18048. DOI:10.1371/journal.pone.0018048
[2] Bailey IR, et al. Optimization of Thermolytic Response to A1 Adenosine Receptor Agonists in Rats. J Pharmacol Exp Ther. 2017 Sep;362(3):424-430. DOI:10.1124/jpet.117.241315

CAPADENOSON Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CAPADENOSON manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Capadenoson 544417-40-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Capadenoson 544417-40-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Career Henan Chemical Co

Product: Capadenoson 544417-40-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

544417-40-5, CAPADENOSONRelated Search:

Palonosetron CAPADENOSON

BAY 68-4986

Capadenoson, BAY 68-4986

CAPADENOSON

2-Amino-6-[[[2-(4-chlorophenyl)-4-thiazolyl]methyl]thio]-4-[4-(2-hydroxyethoxy)phenyl]-3,5-pyridinedicarbonitrile

2-amino-6-[[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile

CS-1666

3,5-Pyridinedicarbonitrile, 2-amino-6-[[[2-(4-chlorophenyl)-4-thiazolyl]methyl]thio]-4-[4-(2-hydroxyethoxy)phenyl]-

2-Amino-6-(((2-(4-chlorophenyl)thiazol-4-yl)methyl)thio)-4-(4-(2-hydroxyethoxy)phenyl)pyridine-3,5-dicarbonitrile

Adenosine Receptor,P1 receptor,Inhibitor,inhibit,Capadenoson

Capadenoson, 10 mM in DMSO

544417-40-5

C25H18ClN5O2S2