5-BROMO-2-IODOANILINE
Uses- Product Name
- 5-BROMO-2-IODOANILINE
- CAS No.
- 64085-52-5
- Chemical Name
- 5-BROMO-2-IODOANILINE
- Synonyms
- 5-BROMO-2-IODOANILINE;5-Bromo-2-iodobenzenamine;BenzenaMine, 5-broMo-2-iodo-
- CBNumber
- CB91092665
- Molecular Formula
- C6H5BrIN
- Formula Weight
- 297.92
- MOL File
- 64085-52-5.mol
5-BROMO-2-IODOANILINE Property
- Melting point:
- 55 °C(Solv: hexane (110-54-3); ethyl ether (60-29-7))
- Boiling point:
- 309.5±27.0 °C(Predicted)
- Density
- 2.292±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- pka
- 1.46±0.10(Predicted)
- form
- powder
- color
- Light gold (hint of peach)
- InChI
- InChI=1S/C6H5BrIN/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2
- InChIKey
- KISIGYZVSJKAEK-UHFFFAOYSA-N
- SMILES
- C1(N)=CC(Br)=CC=C1I
Safety
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- OR51804
- Product name
- 5-Bromo-2-iodoaniline
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB150715
- Product name
- 5-Bromo-2-iodoaniline
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- OR51804
- Product name
- 5-Bromo-2-iodoaniline
- Packaging
- 5g
- Price
- $138
- Updated
- 2021/12/16
- Product number
- 3630-S-04
- Product name
- 5-Bromo-2-iodoaniline
- Packaging
- 5G
- Price
- $152
- Updated
- 2021/12/16
- Product number
- V7071
- Product name
- 5-Bromo-2-iodoaniline
- Packaging
- 25g
- Price
- $188
- Updated
- 2021/12/16
5-BROMO-2-IODOANILINE Chemical Properties,Usage,Production
Uses
5-Bromo-2-iodoaniline can be used as a pharmaceutical and chemical synthesis intermediate. If 5-Bromo-2-iodoaniline is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and thoroughly wash the skin with soap and water. If discomfort persists, seek medical attention.
Synthesis
112671-42-8
64085-52-5
The general procedure for the synthesis of 5-bromo-2-iodoaniline from 4-bromo-1-iodo-2-nitrobenzene was as follows: 4-bromo-1-iodo-2-nitrobenzene (8.38 g, 109.6 mmol) was dissolved in a mixed solvent of acetic acid (AcOH, 45 mL) and ethanol (EtOH, 45 mL) at room temperature, followed by the addition of powdered iron (Fe, 6.12 g 109.6 mmol). The reaction mixture was heated to 100 °C and stirred for 1.3 h, after which it was cooled to room temperature. The reaction mixture was diluted with ether (Et2O, 90 mL) and washed with saturated aqueous sodium bicarbonate (NaHCO3) solution (200 mL). The organic layer was separated and the aqueous layer was further extracted with ether (3 x 60 mL). All organic layers were combined, washed with brine (300 mL), dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel as stationary phase, hexane/ethyl acetate=19:1 as eluent) to afford the target product 5-bromo-2-iodoaniline (6.89 g, 91% yield) as a light yellow solid.
References
[1] Heterocycles, 2009, vol. 79, # C, p. 805 - 820
[2] Tetrahedron, 2013, vol. 69, # 45, p. 9481 - 9493
[3] Synthesis, 2008, # 13, p. 2039 - 2044
[4] Chemical & Pharmaceutical Bulletin, 1987, vol. 35, # 5, p. 1823 - 1828
[5] Patent: WO2011/119860, 2011, A1. Location in patent: Page/Page column 90
5-BROMO-2-IODOANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-2-IODOANILINE manufacturers
- Product
- 5-BROMO-2-IODOANILINE 64085-52-5
- Price
- US $1.00-4.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2025-09-05
- Product
- 5-BROMO-2-IODOANILINE 64085-52-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2024-11-18
- Product
- 5-BROMO-2-IODOANILINE 64085-52-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-11