Sevelamer
- Product Name
- Sevelamer
- CAS No.
- 52757-95-6
- Chemical Name
- Sevelamer
- Synonyms
- Hsdb 7608;Sevelamer;Sevelamer [inn:ban];Epichlorohydrin-PAA 25 copolymer;Allylamine-epichlorohydrin copolymer;Allylamine polymer with 1-chloro-2,3-epoxypropane;2-Propen-1-amine, polymer with (chloromethyl)oxirane;Oxirane, (chloromethyl)-, polymer with 2-propen-1-amine
- CBNumber
- CB91106827
- Molecular Formula
- C6H12ClNO
- Formula Weight
- 149.62
- MOL File
- 52757-95-6.mol
Sevelamer Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
Safety
- Hazardous Substances Data
- 52757-95-6(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- DC10310
- Product name
- Sevelamer
- Purity
- >98%
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- DC10310
- Product name
- Sevelamer
- Purity
- >98%
- Packaging
- 1g
- Price
- $400
- Updated
- 2021/12/16
Sevelamer Chemical Properties,Usage,Production
Uses
Antihyper-phosphatemic.
brand name
Renagel (Genzyme).
Pharmaceutical Applications
In patients on dialysis, Sevelamer or lanthanum salts can be used to maintain normal phosphate blood levels. Sevelamer is a polymer containing amine groups. These protonated amine groups can react with the negatively charged phosphate groups via ionic binding and prevent absorption of phosphate from the gut. Sevelamer is a hydrogel containing cross-linked polyallylamine chains. The negatively charged phosphate can be bound to the positively charged amine groups of the hydrogel in the intestines and removed via the faeces.
Clinical Use
Phosphate-binding agent
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: reduces bioavailability of
ciprofloxacin.
Ciclosporin: possibly reduces ciclosporin
concentration.
Calcitriol: absorption may be impaired by sevelamer.
Mycophenolate: may reduce mycophenolate levels.
Tacrolimus: possibly reduces tacrolimus
concentration.
Thyroid hormones: possibly reduces levothyroxine
concentration.
Metabolism
Sevelamer is not systemically absorbed.