5-Bromo-2-(trifluoromethoxy)aniline

Product Name: 5-Bromo-2-(trifluoromethoxy)aniline
CAS No.: 886762-08-9
Chemical Name: 5-Bromo-2-(trifluoromethoxy)aniline
Synonyms: 5-Bromo-2-(trifluoromethoxy)aniline;5-Bromo-2-trifluoromethoxy-phenylamine;2-Amino-4-bromo-trfluoromethoxybenzene;3-Amino-4-(trifluoromethoxy)bromobenzene;Benzenamine, 5-bromo-2-(trifluoromethoxy)-;3-Amino-4-(trifluoromethoxy)bromobenzene98%
CBNumber: CB91107309
Molecular Formula: C7H5BrF3NO
Formula Weight: 256.02
MOL File: 886762-08-9.mol

More

Less

5-Bromo-2-(trifluoromethoxy)aniline Property

Boiling point:: 230.2±35.0 °C(Predicted)
Density: 1.726±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 1.38±0.10(Predicted)
form: liquid
color: Pale yellow
InChI: InChI=1S/C7H5BrF3NO/c8-4-1-2-6(5(12)3-4)13-7(9,10)11/h1-3H,12H2
InChIKey: FOJWHUFRHXEUBA-UHFFFAOYSA-N
SMILES: C1(N)=CC(Br)=CC=C1OC(F)(F)F

More

Less

Safety

Hazard Codes: Xi
RIDADR: UN2811
HS Code: 2922500090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B810638
Product name: 5-Bromo-2-(trifluoromethoxy)aniline
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J97997
Product name: 5-Bromo-2-(trifluoromethoxy)aniline
Packaging: 100g
Price: $85
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4656-B-52
Product name: 5-Bromo-2-(trifluoromethoxy)aniline
Purity: 98%
Packaging: 5G
Price: $16
Updated: 2021/12/16

AK Scientific

Product number: J97997
Product name: 5-Bromo-2-(trifluoromethoxy)aniline
Packaging: 25g
Price: $30
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4656-B-52
Product name: 5-Bromo-2-(trifluoromethoxy)aniline
Purity: 98%
Packaging: 25g
Price: $56
Updated: 2021/12/16

More

Less

5-Bromo-2-(trifluoromethoxy)aniline Chemical Properties,Usage,Production

Description

5-Bromo-2-(trifluoromethoxy)aniline has a wide range of applications in scientific research. It is used as a reagent in organic synthesis and as a catalyst in polymerization reactions. It is also used as a building block for the synthesis of other organic compounds, such as pharmaceuticals and agrochemicals. It is also used in the synthesis of heterocyclic compounds and in the preparation of metal complexes.

Uses

5-Bromo-2-(trifluoromethoxy)aniline (5-BTA) is a drug with inhibitory activity against cell proliferation and has been shown to be effective in inhibiting the growth of certain cancer cells, such as those expressing tyrosine kinase isoforms. 5-BTA is also capable of blocking cell proliferation through inhibition of other enzymes (e.g., protein kinases). The oral Bioavailability of 5-BTA has been demonstrated in rats and mice. A2780 cells are human lung cancer cells with mutations in the gene encoding tyrosine kinase. Selectivity for tyrosine kinase isoforms was observed in vitro and in vivo.

Synthesis

95668-20-5

886762-08-9

Synthesis of 5-bromo-2-(trifluoromethoxy)aniline (1): to a solution of 4-bromo-2-nitro-1-(trifluoromethoxy)benzene (2.0 g, 7.0 mmol) in acetic acid (10.0 mL) was added powdered iron (1.0 g, 17.9 mmol) batchwise at 0-10 °C. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the acetic acid was removed by distillation and the residue was diluted with water and the pH was adjusted to alkaline with saturated sodium bicarbonate solution. Subsequently, the aqueous phase was extracted with ethyl acetate (2 x 50 mL). The organic layers were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the brown colloidal solid product 1 (1.2 g, 70% yield).1H NMR (400 MHz, DMSO-d6): δ 5.68 (s, 2H), 6.65-6.66 (dd, J=2.4 Hz, 6.2 Hz, 1H), 6.95-6.96 (d, J=2.5 Hz. 1H), 7.01-7.01 (dd, J=1.4Hz, 8.6Hz, 1H). ms m/z (M+H): 256.3.

References

[1] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00758; 00892
[2] Patent: EP3150592, 2017, A1. Location in patent: Paragraph 0126; 0127; 0128

5-Bromo-2-(trifluoromethoxy)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-Bromo-2-(trifluoromethoxy)aniline Suppliers

China 159 India 3 United Kingdom 2 United States 10 Global 174

Hubei Changxinsheng Chemical Co., Ltd

Tel: 18971203904
Email: 1601302530@qq.com
Country: China
ProdList: 492
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

More

Less

View Lastest Price from 5-Bromo-2-(trifluoromethoxy)aniline manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Amino-4-(trifluoromethoxy)BromoBenzene 886762-08-9
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-17

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 5-Bromo-2-(trifluoromethoxy)aniline 886762-08-9
Price: US $100.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-13

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 5-Bromo-2-(Trifluoromethoxy)Aniline 886762-08-9
Price: US $100.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-15

886762-08-9, 5-Bromo-2-(trifluoromethoxy)anilineRelated Search:

5-BroMo-2-(trifluoroMethoxy)phenol 3-NITRO-4-(TRIFLUOROMETHOXY)BROMOBENZENE LABOTEST-BB LT01143471 1-Bromo-4-(trifluoromethoxy)benzene 5-Bromo-2-(trifluoromethoxy)aniline

3-Amino-4-(trifluoromethoxy)bromobenzene98%

3-Amino-4-(trifluoromethoxy)bromobenzene

5-Bromo-2-trifluoromethoxy-phenylamine

2-Amino-4-bromo-trfluoromethoxybenzene

5-Bromo-2-(trifluoromethoxy)aniline

Benzenamine, 5-bromo-2-(trifluoromethoxy)-

886762-08-9

Fluorine series