Phenactropinium chloride
- Product Name
- Phenactropinium chloride
- CAS No.
- 3784-89-2
- Chemical Name
- Phenactropinium chloride
- Synonyms
- Phenactropinium;Phenactropinium chloride;3-[Hydroxy(phenyl)acetoxy]-8-methyl-8-(2-oxo-2-phenylethyl)-8-azoniabicyclo[3.2.1]octane;(8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate chloride;(8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenyl-ethanoate chloride;2-hydroxy-2-phenyl-acetic acid (8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) ester chloride
- CBNumber
- CB91116431
- Molecular Formula
- C24H28ClNO4
- Formula Weight
- 0
- MOL File
- 3784-89-2.mol
Phenactropinium chloride Property
- Melting point:
- 195-197°
N-Bromosuccinimide Price
- Product number
- API0012227
- Product name
- PHENACTROPINIUM CHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.43
- Updated
- 2021/12/16
Phenactropinium chloride Chemical Properties,Usage,Production
Originator
Trophenium ,American Cyanamid (AHP), US ,1961
Manufacturing Process
330 g (1.2 M) of homatropine were dissolved in 1 liter of dry methyl ethyl ketone and gently refluxed on a water-bath during the gradual addition of a solution of 204 g (1.32 M) redistilled phenacyl chloride in 200 ml of the same solvent. After 10 to 15 minutes 1 g of previously prepared homatropine phenacyl chloride was added to avoid formation of a supersaturated solution of the quaternary compound. Reflux was continued for 9 hours, then the thick suspension was allowed to cool, filtered and washed with 200 ml methyl ethyl ketone to yield 490 g (95%) slightly creamy solid, MP 188°C to 191°C.
For purification the crude quaternary salt was dissolved in hot ethyl alcohol (2 ml/g) and warm dry acetone (8 ml/g) was stirred into the clear filtrate. On cooling, 387 g (78 % recovery) of a pure white powder, MP 195°C to 197°C, were obtained, in which the ionizable chlorine assayed at 99.7% of the theoretical value.
Therapeutic Function
Antihypertensive
Phenactropinium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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