Ifetroban
- Product Name
- Ifetroban
- CAS No.
- 143443-90-7
- Chemical Name
- Ifetroban
- Synonyms
- BMS180291;Ifetroban;BMS-180291;BMS 180291-02;Benzenepropanoic acid, 2-[[(1S,2R,3S,4R)-3-[4-[(pentylamino)carbonyl]-2-oxazolyl]-7-oxabicyclo[2.2.1]hept-2-yl]methyl]-
- CBNumber
- CB91116567
- Molecular Formula
- C25H32N2O5
- Formula Weight
- 440.537
- MOL File
- 143443-90-7.mol
Ifetroban Property
- form
- Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BRS0000378
- Product name
- IFETROBAN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.48
- Updated
- 2021/12/16
Ifetroban Chemical Properties,Usage,Production
Uses
Antithrombotic.
Definition
ChEBI: Ifetroban is a monocarboxylic acid and a member of benzenes.
in vivo
Ifetroban (50 mg/kg/d; p.o.; 2 d prior to, through 28 d after tumor injection) decreases hematogenous metastasis of multiple cancer types without in mice model[2].
Ifetroban (50 mg/kg/d; p.o.; 12 d) does not affect primary tumor growth but decreases tumor vessels in mice with 4T1 (mouse mammary cancer)[2].
Ifetroban (BMS 180,291; 1 and 3 mg/kg, p.o.) inhibits aggregation and antagonizes TP-receptor in monekys. Ifetroban (3 mg/kg, i.v.) causes only marginal and transient hemodynamic effects in anesthetized African green monkeys[3].
| Animal Model: | Athymic (nu/nu) Balb/C female mice injected with tumor cells: 4T1 (mouse mammary cancer), MDA-MB-231 (human breast cancer), MiaPaCa2 (human pancreatic cancer), and A549 (human lung cancer) model[2] |
| Dosage: | 50 mg/kg; via 25 μL vehicle (4% sucrose in sterile water) |
| Administration: | Oral gavage; pretreated before 2 days and treated 28 days later |
| Result: | Decreased the percentage of mice harboring MDA-MB-231 lung metastases from 90% to 20%, and mice with A549 lung metastases from 60% to 10%. |
IC 50
TXA2/TP
Ifetroban Preparation Products And Raw materials
Raw materials
Preparation Products
Ifetroban Suppliers
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- 13921770081
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