ChemicalBook > CAS DataBase List > 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine
1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine
- Product Name
- 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine
- CAS No.
- 141699-58-3
- Chemical Name
- 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine
- Synonyms
- 1-Boc-3-(mesyloxy)azetidine;N-Boc-3-methanesulfonyloxyazetidine;1-Boc-3-methanesulfonyloxy-azetidine;N-Boc 3-(Methylsulfonyloxy)azetidine;1-N-BOC-3-METHANESULFONYLOXYAZETIDINE;1-(tert-Butoxycarbonyl)-3-(mesyloxy)azetidine;tert-butyl 3-methylsulfonyloxyazetidine-1-carboxylate;1-(tert-butoxycarbonyl)azetidine-3-yl-methanesulfonate;tert-Butyl 3-[(methylsulfonyl)oxy]azetane-1-carboxylate;1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine
- CBNumber
- CB91116921
- Molecular Formula
- C9H17NO5S
- Formula Weight
- 251.3
- MOL File
- 141699-58-3.mol
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1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine Property
- Melting point:
- 69 °C
- Boiling point:
- 378.5±31.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- -4.18±0.40(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C9H17NO5S/c1-9(2,3)14-8(11)10-5-7(6-10)15-16(4,12)13/h7H,5-6H2,1-4H3
- InChIKey
- XXBDTKYKFFIAEY-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CC(OS(C)(=O)=O)C1
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SYX00004
- Product name
- tert-Butyl 3-[(methylsulfonyl)oxy]-1-azetanecarboxylate
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $30.7
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B5801
- Product name
- tert-Butyl 3-[(Methylsulfonyl)oxy]azetidine-1-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $40
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B5801
- Product name
- tert-Butyl 3-[(Methylsulfonyl)oxy]azetidine-1-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $156
- Updated
- 2025/07/31
TRC
- Product number
- B423283
- Product name
- tert-Butyl3-(Methanesulfonyloxy)azetidine-1-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
AK Scientific
- Product number
- 6901AA
- Product name
- 1-Boc-3-Methanesulfonyloxyazetidine
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
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1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine Chemical Properties,Usage,Production
Synthesis
124-63-0
141699-55-0
141699-58-3
Preparation of Example 26-2: tert-butyl 3-((methylsulfonyl)oxy)azetidine-1-carboxylate Under a nitrogen atmosphere, methanesulfonyl chloride (2.57 mL, 33.3 mmol) and triethylamine (11.6 mL, 83.1 mmol) were sequentially added to a solution of tetrahydrofuran (100 mL) containing N-Boc-3-hydroxyazetidine (4.8 g, 27.7 mmol). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution was added to the reaction solution and the mixture was diluted with ethyl acetate. The organic layer was separated, washed with saturated brine and subsequently dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent ratio: n-heptane/ethyl acetate = 9:1 to 1:1) to quantitatively obtain N-Boc-3-methylsulfonyloxyazetidine. 1H-NMR (CDCl3) δ (ppm): 1.45 (9H, s), 3.07 (3H, s), 4.03-4.18 (2H, m), 4.22-4.36 (2H, m), 5.12-5.27 (1H, m).
References
[1] Patent: US2014/235614, 2014, A1. Location in patent: Paragraph 0570; 0571; 0572
[2] Patent: EP1340757, 2003, A1
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 18, p. 7731 - 7757
[4] Patent: WO2018/102419, 2018, A1. Location in patent: Paragraph 0344; 0345; 0346; 0347
[5] Patent: US2012/10182, 2012, A1. Location in patent: Page/Page column 40
1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine manufacturers
Career Henan Chemical Co
- Product
- 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine 141699-58-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19
141699-58-3, 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidineRelated Search:
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1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine
1-BOC-3-(TOLUENE-4-SULFONYLOXY)-AZETIDINE
1-N-Boc-3-hydroxyazetidine