C75

Product Name: C75
CAS No.: 191282-48-1
Chemical Name: C75
Synonyms: C75;C75 (trans);C75 (racemic);C 75 trC-75 trans-racemic;4-METHYLENE-2-OCTYL-5-OXOTETRAHYDROFURAN-3-CARBOXYLIC ACID;TETRAHYDRO-4-METHYLENE-2-OCTYL-5-OXO-3-FURANCARBOXYLIC ACID;(2R,3S)-4-METHYLIDENE-5-OXO-2-N-OCTYL-OXOLANE-3-CARBOXYLIC ACID;trans-4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid;trans-Tetrahydro-4-Methylene-2-octyl-5-oxo-3-furancarboxylic Acid;(2S,3R)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
CBNumber: CB9114164
Molecular Formula: C14H22O4
Formula Weight: 254.32
MOL File: 191282-48-1.mol

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C75 Property

Boiling point:: 432.1±45.0 °C(Predicted)
Density: 1.08±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 18 mg/mL
form: solid
pka: 3.08±0.40(Predicted)
color: off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10005270
Product name: (±)-C75
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 10005270
Product name: (±)-C75
Purity: ≥98%
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 10005270
Product name: (±)-C75
Purity: ≥98%
Packaging: 10mg
Price: $172
Updated: 2024/03/01

Usbiological

Product number: 021558
Product name: trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid
Packaging: 5mg
Price: $460
Updated: 2021/12/16

TRC

Product number: T293960
Product name: trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylicAcid
Packaging: 50mg
Price: $1320
Updated: 2021/12/16

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C75 Chemical Properties,Usage,Production

Uses

trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid is a well-known fatty acid synthase (FAS) inhibitor. Studies show that trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid is a cell cycle arrest inducer in hepatocellular carcinoma (HCC) cell lines. It has also been shown to blocks resistin-induced increases in lipid accumulation by human macrophages.

Definition

ChEBI: (2R,3S)-C75 is a 4-methylidene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid that has 2R,3S-configuration. It is an enantiomer of a (2S,3R)-C75.

Biological Activity

c 75 is an inhibitor of fatty acid synthase [1].fatty acid synthase (fas) is a multi-enzyme protein that catalyzes fatty acid synthesis. its main function is to catalyze the synthesis of palmitate from acetyl-coa and malonyl-coa. fas is a target for anticancer drug [1].in human breast cancer cells, c 75 reacted preferentially with fas and inhibited fas. the antitumor activity of c 75 is likely mediated by its inhibition of fas [1]. in primary cortical neurons, c 75 inhibited fas activity and increased the activity of carnitine palmitoyltransferase-1 (cpt-1) and fatty acid oxidation, which suggested that c 75 might influence cellular energy balance through regulation of these metabolic pathways. also, c 75 altered neuronal atp levels in a biphasic manner (decreasing initially, followed by a prolonged increase above control levels). the amp-activated protein kinase (ampk) activity was also influenced by c 75 [2]. in human melanoma a-375 cells, c 75 inhibited cell growth through activation of caspase-dependent apoptosis [3].in diet induced obese (dio) mice, chronic c 75 treatment reduced food intake and increased energy expenditure due to increased fatty acid oxidation. c 75 significantly reduced adipose tissue. the reduced food intake was accompanied by an increase in amphetamine and cocaine-related transcript expression [4].

storage

Store at +4°C

References

[1]. kuhajda fp, pizer es, li jn, et al. synthesis and antitumor activity of an inhibitor of fatty acid synthase. proc natl acad sci u s a, 2000, 97(7): 3450-3454.
[2]. landree le, hanlon al, strong dw, et al. c75, a fatty acid synthase inhibitor, modulates amp-activated protein kinase to alter neuronal energy metabolism. j biol chem, 2004, 279(5): 3817-3827.
[3]. ho ts, ho yp, wong wy, et al. fatty acid synthase inhibitors cerulenin and c75 retard growth and induce caspase-dependent apoptosis in human melanoma a-375 cells. biomed pharmacother, 2007, 61(9): 578-587.
[4]. thupari jn, kim ek, moran th, et al. chronic c75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. am j physiol endocrinol metab, 2004, 287(1): e97-e104.

C75 Preparation Products And Raw materials

Raw materials

Preparation Products

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C75 Suppliers

Canada 1 China 78 India 1 Switzerland 2 United Kingdom 5 United States 20 Global 107

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191282-48-1, C75Related Search:

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TETRAHYDRO-4-METHYLENE-2-OCTYL-5-OXO-3-FURANCARBOXYLIC ACID

C75

(2S,3R)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid

(2R,3S)-4-METHYLIDENE-5-OXO-2-N-OCTYL-OXOLANE-3-CARBOXYLIC ACID

(2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylicacid

(2R,3S)-rel-Tetrahydro-4-Methylene-2-octyl-5-oxo-3-furancarboxylic Acid

trans-Tetrahydro-4-Methylene-2-octyl-5-oxo-3-furancarboxylic Acid

trans-4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid

C75 (trans)

C75 (racemic)

4-METHYLENE-2-OCTYL-5-OXOTETRAHYDROFURAN-3-CARBOXYLIC ACID

trans-C 75 (trans-4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid)

C 75 trC-75 trans-racemic

3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-, (2R,3S)-rel-

trans-C-75,Fatty Acid Synthase (FASN),Inhibitor,inhibit,trans C75,trans-C75,transC75

(2R,3S)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid

191282-48-1

pharmacetical