3'-DEPHOSPHOCOENZYME A

Product Name: 3'-DEPHOSPHOCOENZYME A
CAS No.: 3633-59-8
Chemical Name: 3'-DEPHOSPHOCOENZYME A
Synonyms: Dephospho-CoA;3'-dephospho-CoA;dephosphocoenzyme A;3'-DEPHOSPHOCOENZYME A;3'-Dephosphocoenzyme A;3'-O-dephosphono-coenzyme A;Coenzyme A, 3'-O-dephosphono-;3'-DEPHOSPHOCOENZYME A FREE ACID;3'-Dephosphocoenzyme A >=90% (HPLC);Coenzyme A Impurity 26 (3′-O-dephosphono Coenzyme A)
CBNumber: CB9115282
Molecular Formula: C21H35N7O13P2S
Formula Weight: 687.55
MOL File: 3633-59-8.mol

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3'-DEPHOSPHOCOENZYME A Property

Density: 1.85±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Water: 50 mg/ml
form: A crystalline solid
pka: 1.16±0.50(Predicted)
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D3385
Product name: 3′-Dephosphocoenzyme A
Purity: ≥90% (HPLC)
Packaging: 5mg
Price: $225
Updated: 2025/07/31

Sigma-Aldrich

Product number: D3385
Product name: 3′-Dephosphocoenzyme A
Purity: ≥90% (HPLC)
Packaging: 25mg
Price: $807
Updated: 2025/07/31

Cayman Chemical

Product number: 27390
Product name: 3''-Dephosphocoenzyme A
Packaging: 1mg
Price: $60
Updated: 2024/03/01

Cayman Chemical

Product number: 27390
Product name: 3''-Dephosphocoenzyme A
Packaging: 10mg
Price: $351
Updated: 2024/03/01

Cayman Chemical

Product number: 27390
Product name: 3''-Dephosphocoenzyme A
Packaging: 5mg
Price: $190
Updated: 2024/03/01

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3'-DEPHOSPHOCOENZYME A Chemical Properties,Usage,Production

Description

3''-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A (CoA; Item Nos. 16147 | 21499 | 21722) from pantothenic acid (vitamin B₅; ). It is phosphorylated by CoA synthase in humans to form CoA. 3''-Dephosphocoenzyme A can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription.

Uses

Dephosphocoenzyme A is the direct precursor of coenzyme A. It is used for the synthesis of coenzyme A by bifunctional CoA Synthase (CoASy, 4′-phosphopantetheine adenylyltransferase/dephospho-CoA kinase) which performs the transfer of the γ-phosphate of ATP to dephosphocoenzyme A.

Definition

ChEBI: An adenosine 5'-phosphate that is coenzyme A in which the phosphate group at position 3' has been replaced by a hydrogen atom. It is an intermediate metabolite in pantothenate and CoA biosynthesis

Biochem/physiol Actions

3′-Dephosphocoenzyme A (DepCoA), also called desphosphoCoA (dpCoA), is synthesized from 4-phosphopantetheine by the enzyme phosphopanthetheine adenylyltransferase. It is an intermediate in coenzyme A biosynthetic pathway. In the presence of dephospho-CoA kinase (CoaE), dephosphocoenzyme A is converted to coenzyme A. 3′-Dephosphocoenzyme shares adenosine-diphosphate substructure as like the purines and is a non-canonical nucleotide and is an initiator of transcription initiation. It is routinely used in in vitro transcription studies to initiate RNA synthesis.

IC 50

Human Endogenous Metabolite

References

[1] HUANG F. Efficient incorporation of CoA, NAD and FAD into RNA by in vitro transcription.[J]. Nucleic Acids Research, 2003, 31 3: e8. DOI: 10.1093/nar/gng008
[2] KRISHNA SAPKOTA Faqing H. Efficient one-pot enzymatic synthesis of dephospho coenzyme A[J]. Bioorganic Chemistry, 2018, 76: Pages 23-27. DOI: 10.1016/j.bioorg.2017.10.012

3'-DEPHOSPHOCOENZYME A Preparation Products And Raw materials

Raw materials

Preparation Products

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3'-DEPHOSPHOCOENZYME A Suppliers

China 27 Switzerland 1 United Kingdom 1 United States 5 Global 34

Shanghai Aladdin Bio-Chem Technology Co.,LTD

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Sigma-Aldrich

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Shanghai EFE Biological Technology Co., Ltd.

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Shanghai Hongye Biotechnology Co. Ltd

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TargetMol Chemicals Inc.

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NewCan Biotech Limited

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Energy Chemical

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TargetMol Chemicals Inc.

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3633-59-8, 3'-DEPHOSPHOCOENZYME ARelated Search:

COENZYME A TRILITHIUM SALT MYRISTOYL COENZYME A C14:0 LITHIUM SALT COENZYME A TRILITHIUM SALT DIHYDRATE ACETYL COENZYME A (C2:0) LITHIUM LAUROYL COENZYME A C12:0 LITHIUM SALT ACETOACETYL COENZYME A, TETRALITHIUM PENTAHYDRATE LITHIUM SALT C4:0 N-OCTADECANOYL COENZYME A LITHIUM SALT ACETOACETYL COENZYME A LITHIUM SALT CIS-9-OCTADECENOYL COENZYME A LITHIUM SALT CAPROYL COENZYME A TRILITHIUM SALT METHYLMALONYL COENZYME A LITHIUM 3'-DEPHOSPHOCOENZYME A LINOLEOYL COENZYME A (C18:2) LITHIUM SALT

3'-DEPHOSPHOCOENZYME A FREE ACID

[5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]-phosphoryl]oxy-phosphinic acid

Dephospho-CoA

dephosphocoenzyme A

3'-dephospho-CoA

Coenzyme A, 3'-O-dephosphono-

3'-Dephosphocoenzyme A >=90% (HPLC)

3'-O-dephosphono-coenzyme A

3'-Dephosphocoenzyme A

3'-DEPHOSPHOCOENZYME A

Coenzyme A Impurity 26 (3′-O-dephosphono Coenzyme A)

3633-59-8

C21H33N7O13P2S2Li

C21H35N7O13P2S

BioChemical

Lipid Library

Metabolomics

Metabolic Libraries

Acyl Transfer ReagentsMetabolic Pathways

Lipid LibraryMetabolites and Cofactors on the Metabolic Pathways Chart

LipidMetabolomics

Cofactor

Cofactors

Enzymes, Inhibitors, and Substrates

Metabolic Libraries

Metabolites and Cofactors on the Metabolic Pathways Chart

Pantothenate

Pharmaceutical