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MONACOLIN J

Product Name
MONACOLIN J
CAS No.
79952-42-4
Chemical Name
MONACOLIN J
Synonyms
(4R,6R)-;monacolin J;Simvastatin?imp?H;Lovastatin Impurity 8;Lovastatin Diol Lactone;Lovastatin Lactone Diol;SiMvastatin Lactone Diol;Simvastatin EP Impurity H;Simvastatin EP Impurity 8;Simvastatin EP Impurity H (4R-Isomer)
CBNumber
CB91175997
Molecular Formula
C19H28O4
Formula Weight
320.42322
MOL File
79952-42-4.mol
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MONACOLIN J Property

Melting point:
50-53°C
Boiling point:
535.7±50.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Chloroform (Slightly), DMF, DMSO, Methanol (Slightly)
form 
Solid
pka
13.49±0.40(Predicted)
color 
White to Pale Yellow
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
H941625
Product name
6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
Packaging
100mg
Price
$1390
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0005960
Product name
6(R)-(2-(8(S)-HYDROXY)-2(S),6(R)-DIMETHYL-1,2,6,7,8,8A(R)-HEXAHYDRO-1(S)-NAPHTHYL)ETHYL-4(R)-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONE
Purity
95.00%
Packaging
100MG
Price
$1963.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0005960
Product name
6(R)-(2-(8(S)-HYDROXY)-2(S),6(R)-DIMETHYL-1,2,6,7,8,8A(R)-HEXAHYDRO-1(S)-NAPHTHYL)ETHYL-4(R)-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONE
Purity
95.00%
Packaging
10MG
Price
$750.75
Updated
2021/12/16
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MONACOLIN J Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

Monacolin J is a Simvastatin intermediate; Lovastatin analog has the activities of decreasing blood cholesterol and low-d. lipoprotein, can be used to preparation hypolipidemic medicine.

Definition

ChEBI: A polyketide that is monacolin L bearing an additional hydroxy substituent at position 8.

MONACOLIN J Preparation Products And Raw materials

Raw materials

Preparation Products

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79952-42-4, MONACOLIN JRelated Search:

2,3-DEHYDROLOVASTATIN ACID SODIUM SALT DES (2-METHYLBUTYRATE) LOVASTATIN HYDROXY ACID SODIUM SALT Lovastatin Lovastatin sodium salt Lovastatin DiMer Dehydro Lovastatin Polycaprolactone Dehydro Simvastatin ACETYLSIMVASTATIN SIMVASTATIN, SODIUM SALT SiMvastatin Hydroxy Acid Ethyl Ester Simvastatin Hydroxy Acid Methyl Ester

  • (4R,6R)-4-Hydroxy-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one
  • 6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
  • (4R,6R)-
  • SiMvastatin Lactone Diol
  • Lovastatin Lactone Diol
  • Lovastatin Diol Lactone
  • Simvastatin EP Impurity H
  • Lovastatin Impurity 8
  • monacolin J
  • 2H-Pyran-2-one, 6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-, (4R,6R)-
  • Simvastatin?imp?H
  • Lovastatin Lactone Diol (Simvastatin EP Impurity H/ Simvastatin Lactone Diol)
  • Simvastatin EP Impurity H (Simvastatin Lactone Diol/ Lovastatin Lactone Diol)
  • (4RS,6R)-4-Hydroxy-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8ahexahydronaphthalen-1-yl]ethyl]tetrahydro-2H-pyran-2-one
  • Autophagy,inhibit,Inhibitor,Monacolin J,HMG-CoA Reductase (HMGCR)
  • Simvastatin EP Impurity H (4R)-Diastereomer
  • Simvastatin EP Impurity H (4R-Isomer)
  • Simvastatin EP Impurity 8
  • Lovastatin Diol Lactone ((4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one)
  • 79952-42-4
  • Chiral Reagents
  • Drug Analogues
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals