ChemicalBook > CAS DataBase List > MONACOLIN J

MONACOLIN J

Product Name: MONACOLIN J
CAS No.: 79952-42-4
Chemical Name: MONACOLIN J
Synonyms: (4R,6R)-;monacolin J;Simvastatin?imp?H;Lovastatin Impurity 8;Lovastatin Diol Lactone;Lovastatin Lactone Diol;SiMvastatin Lactone Diol;Simvastatin EP Impurity H;Simvastatin EP Impurity 8;Monacolin J, 10 mM in DMSO
CBNumber: CB91175997
Molecular Formula: C19H28O4
Formula Weight: 320.42322
MOL File: 79952-42-4.mol

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MONACOLIN J Property

Melting point:: 50-53°C
Boiling point:: 535.7±50.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: Chloroform (Slightly), DMF, DMSO, Methanol (Slightly)
form: Solid
pka: 13.49±0.40(Predicted)
color: White to Pale Yellow
Stability:: Hygroscopic
InChIKey: ZDFOBOYQVYMVCW-IRUSZSJRSA-N
SMILES: C1(=O)O[C@H](CC[C@@H]2[C@]3([H])C(=C[C@H](C)C[C@@H]3O)C=C[C@@H]2C)C[C@@H](O)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H941625
Product name: 6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
Packaging: 100mg
Price: $1390
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0005960
Product name: 6(R)-(2-(8(S)-HYDROXY)-2(S),6(R)-DIMETHYL-1,2,6,7,8,8A(R)-HEXAHYDRO-1(S)-NAPHTHYL)ETHYL-4(R)-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONE
Purity: 95.00%
Packaging: 10MG
Price: $750.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0005960
Product name: 6(R)-(2-(8(S)-HYDROXY)-2(S),6(R)-DIMETHYL-1,2,6,7,8,8A(R)-HEXAHYDRO-1(S)-NAPHTHYL)ETHYL-4(R)-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONE
Purity: 95.00%
Packaging: 100MG
Price: $1963.5
Updated: 2021/12/16

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MONACOLIN J Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

Monacolin J is a Simvastatin intermediate; Lovastatin analog has the activities of decreasing blood cholesterol and low-d. lipoprotein, can be used to preparation hypolipidemic medicine.

Definition

ChEBI: A polyketide that is monacolin L bearing an additional hydroxy substituent at position 8.

MONACOLIN J Preparation Products And Raw materials

Raw materials

Preparation Products

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79952-42-4, MONACOLIN JRelated Search:

2,3-DEHYDROLOVASTATIN ACID SODIUM SALT DES (2-METHYLBUTYRATE) LOVASTATIN HYDROXY ACID SODIUM SALT Lovastatin Lovastatin sodium salt Lovastatin DiMer Dehydro Lovastatin Polycaprolactone Dehydro Simvastatin ACETYLSIMVASTATIN SIMVASTATIN, SODIUM SALT SiMvastatin Hydroxy Acid Ethyl Ester Simvastatin Hydroxy Acid Methyl Ester

(4R,6R)-4-Hydroxy-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one

6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

(4R,6R)-

SiMvastatin Lactone Diol

Lovastatin Lactone Diol

Lovastatin Diol Lactone

Simvastatin EP Impurity H

Lovastatin Impurity 8

monacolin J

2H-Pyran-2-one, 6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-, (4R,6R)-

Simvastatin?imp?H

Lovastatin Lactone Diol (Simvastatin EP Impurity H/ Simvastatin Lactone Diol)

Simvastatin EP Impurity H (Simvastatin Lactone Diol/ Lovastatin Lactone Diol)

(4RS,6R)-4-Hydroxy-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8ahexahydronaphthalen-1-yl]ethyl]tetrahydro-2H-pyran-2-one

Autophagy,inhibit,Inhibitor,Monacolin J,HMG-CoA Reductase (HMGCR)

Simvastatin EP Impurity H (4R)-Diastereomer

Lovastatin Diol Lactone ((4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one)

Simvastatin EP Impurity 8

Simvastatin EP Impurity H (4R-Isomer)

Lovastatin Diol Lactone ((4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimeth

Monacolin J, 10 mM in DMSO

79952-42-4

Chiral Reagents

Drug Analogues

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals