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CV-6209

Product Name
CV-6209
CAS No.
100488-87-7
Chemical Name
CV-6209
Synonyms
Cv 6209 chloride;CV-6209 (CV 6209;2-(N-Acetyl-N-(2-methoxy-3-octadecylcarbamoyloxypropoxycarbonyl)aminomethyl)-1-ethylpyridinium;2-(2-Acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl- pyridinium Chloride;Pyridinium, 2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-, chloride;Pyridinium, 2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-, chloride (1:1)
CBNumber
CB91176222
Molecular Formula
C34H60ClN3O6
Formula Weight
0
MOL File
100488-87-7.mol
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CV-6209 Property

storage temp. 
Store at -20°C
solubility 
Water: 10 mg/ml
form 
A crystalline solid
color 
Off-white to light yellow
Stability:
Store at -200C.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15955
Product name
CV-6209 (chloride)
Purity
≥95%
Packaging
500μg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
15955
Product name
CV-6209 (chloride)
Purity
≥95%
Packaging
1mg
Price
$165
Updated
2024/03/01
Cayman Chemical
Product number
15955
Product name
CV-6209 (chloride)
Purity
≥95%
Packaging
5mg
Price
$721
Updated
2024/03/01
TRC
Product number
C856000
Product name
CV-6209
Packaging
5mg
Price
$655
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
8606
Product name
CV-6209
Packaging
1mg
Price
$290
Updated
2021/12/16
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CV-6209 Chemical Properties,Usage,Production

Description

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively. It has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 is bioavailable, as it prevents PAF-induced hypotension in rats, while not blocking hypotension triggered by arachidonic acid , histamine, bradykinin , or isoproterenol . CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo.

Chemical Properties

Pale-Yelow Solid

Uses

Competitive PAF receptor antagonist. Inhibits PAF induced human platelet aggregation. Inhibits PAF induced hypotension and lethality.

in vivo

CV-6209 (i.v.) inhibits PAF (0.3 μg/kg; i.v.)-induced hypotension in rats (ED50=0.009 mg/kg) with no effect on the hypotension induced by arachidonic acid, histamine, bradykinin and isoproterenol[1].
CV-6209 (66 μg; i.v.) reduces asparaginase-induced hypersensitivity compared with nonpretreated, sensitized mice[3].

References

[1] Z TERASHITA. CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo.[J]. Journal of Pharmacology and Experimental Therapeutics, 1987, 242 1: 263-268.
[2] H. S. LEONG. Vimentin autoantibodies induce platelet activation and formation of platelet-leukocyte conjugates via platelet-activating factor[J]. Journal of Leukocyte Biology, 2007, 83 2: 263-271. DOI: 10.1189/jlb.0607339
[3] SILVIA MUSIO. Anaphylaxis to a self-peptide in the absence of mast cells or histamine[J]. Laboratory Investigation, 2009, 89 4: 398-405. DOI: 10.1038/labinvest.2009.4

CV-6209 Preparation Products And Raw materials

Raw materials

Preparation Products

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CV-6209 Suppliers

Canada 1 China 34 South Korea 1 Switzerland 1 United States 7 Global 44
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
Email
jkinfo@jkchemical.com
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China
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96815
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Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
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58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
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58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
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sales@rrkchem.com
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China
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57422
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Alfa Chemistry
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+1-5166625404;
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1-516-927-0118
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Info@alfa-chemistry.com
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United States
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20405
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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United States
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32435
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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86-571-88216897,88216896 13588875226
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86-571-88216895
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sales@hzclap.com
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CHINA
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Energy Chemical
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021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
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China
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100488-87-7, CV-6209Related Search:


  • 2-(2-Acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl- pyridinium Chloride
  • 2-(N-Acetyl-N-(2-methoxy-3-octadecylcarbamoyloxypropoxycarbonyl)aminomethyl)-1-ethylpyridinium
  • Cv 6209 chloride
  • Pyridinium, 2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-, chloride
  • CV-6209 (CV 6209
  • Pyridinium, 2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-, chloride (1:1)
  • 100488-87-7
  • C34H60ClN3O6
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Heterocyclic Compounds
  • Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals