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Ganciclovir Mono-O-acetate

Product Name
Ganciclovir Mono-O-acetate
CAS No.
88110-89-8
Chemical Name
Ganciclovir Mono-O-acetate
Synonyms
Monacetyl ganciclor;Gancyclovir Impurity 20;Mono acetyl Ganciclovir;Valganciclovir USP RC E;Ganciclovir Impurity 30;O-Monoacetylganciclovir;Ganciclovir Impurity 16;Mono-O-AcetylGanciclovir;Mono-O-acetateGanciclovir;Ganciclovir Mono-O-acetate
CBNumber
CB91176343
Molecular Formula
C11H15N5O5
Formula Weight
297.27
MOL File
88110-89-8.mol
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Ganciclovir Mono-O-acetate Property

Melting point:
194-197°C
Density 
1.66±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.32±0.20(Predicted)
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H340May cause genetic defects

H351Suspected of causing cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
G235010
Product name
GanciclovirMono-O-acetate
Packaging
25mg
Price
$185
Updated
2021/12/16
ChemScene
Product number
CS-M3368
Product name
2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol
Purity
97.29%
Packaging
100g
Price
$214
Updated
2021/12/16
AK Scientific
Product number
1320EM
Product name
GanciclovirMono-O-acetate
Packaging
1g
Price
$69
Updated
2021/12/16
ChemScene
Product number
CS-M3368
Product name
2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol
Purity
97.29%
Packaging
25g
Price
$71
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000578
Product name
GANCICLOVIR MONO-O-ACETATE
Purity
95.00%
Packaging
50MG
Price
$721.88
Updated
2021/12/16
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Ganciclovir Mono-O-acetate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Ganciclovir derivative.

Synthesis

2466-76-4

82410-32-0

88110-89-8

The general procedure for the synthesis of 2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl acetate from 1-acetylimidazole and 2-amino-9-(((1,3-dihydroxypropan-2- yl)oxy)methyl)-1H-purin-6(9H)-one is as follows: 500.0 g (1.96 mol, 1.0 equiv) of ganciclovir, 244.4 g (2.35 mol, 1.2 eq.) of trimethyl borate and 7.5 kg of toluene were added to the reaction vessel and heated to reflux for 5 hours. The progress of the reaction was monitored by TLC to confirm the complete reaction of the ingredients. The reaction mixture was cooled to room temperature and 396.7 g (3.93 mol, 2.0 eq.) of triethylamine was added, followed by 323.7 g (2.94 mol, 1.5 eq.) of 1-acetylimidazole, and stirred for 6 hours at room temperature. The ratio of monoacetyl ganciclovir to N,O-diacetyl ganciclovir was analyzed by HPLC to be 94:4. The reaction mixture was cooled to 0-10 °C and 2.0 kg of methanol was slowly added dropwise followed by stirring for 2 h at room temperature. The solvent was removed by concentration under reduced pressure, 3.0 kg of ethyl acetate was added, the organic layer was washed with 500 g of water and the aqueous layer was extracted with 500 g of ethyl acetate. The organic layers were combined, concentrated under reduced pressure and recrystallized by ethanol to give 440.9 g of colorless crystal product in 75.7% yield and 99.2% purity.

References

[1] Patent: CN108383840, 2018, A. Location in patent: Paragraph 0033; 0034; 0043; 0045; 0050
[2] Patent: CN108503642, 2018, A. Location in patent: Paragraph 0028-0034; 0039; 0040; 0042-0050; 0053; 0054
[3] Patent: CN108503641, 2018, A. Location in patent: Paragraph 0030; 0031; 0033; 0034; 0040-0051; 0054; 0055
[4] Patent: CN108409739, 2018, A. Location in patent: Paragraph 0033; 0034; 0043; 0045; 0050

Ganciclovir Mono-O-acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ganciclovir Mono-O-acetate manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Ganciclovir Mono-O-acetate 88110-89-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-13
PNP Biotech Co. Ltd
Product
Ganciclovir Mono-O-acetate 88110-89-8
Price
US $0.00/kg
Min. Order
25kg
Purity
98%-99%
Supply Ability
Inquiry
Release date
2022-09-16
Hangzhou ICH Biofarm Co., Ltd
Product
Ganciclovir Mono-O-acetate 88110-89-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.0%min
Supply Ability
10tons
Release date
2023-07-12

88110-89-8, Ganciclovir Mono-O-acetateRelated Search:

Acyclovir N-Methyl-L-valinate Hydrochloride N-Methyl Valganciclovir Hydrochloride N-ForMyl Valacyclovir L-Valine 2-Hydroxyethyl Ester 4-Methylbenzenesulfonate Guanine (S)-Valganciclovir DiMethyl Ether IMpurity DISCONTINUED Cbz-Valaciclovir Bis Valacyclovir (~90%) Bis(L-Valine) Ester Ganciclovir TFA Salt Acyclovir N-Methylene Dimer DVCUGHHGLKCBMT-QVDQXJPCSA-N Valganciclovir Dimer Stereoisomer A, B, C 9-[[2-(α-L-Alanyloxy)ethoxy]methyl]guanine Hydrochloride INDEX NAME NOT YET ASSIGNED Valaciclovir iMpurity D D-Valganciclovir Hydrochloride 9-(1,3-diacetate-2-propoxymethyl)guanine ZCDDBUOENGJMLV-DDWIOCJRSA-N

  • 9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro- 6H-Purin-6-on
  • Ganciclovir Mono-O-acetate
  • Gancyclovir Impurity 20
  • 6h-purin-6-one,9-[[2-(acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro-
  • [2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] acetate
  • 9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro- 6H-Purin-6-one
  • Ganciclovir-Mono-O-acetate(Mono-O-AcetylGanciclovir)
  • 2-[(2-aMino-6-oxo-3,6-dihydro-9H-purin-9-yl)Methoxy]-3-hydroxypropyl acetate
  • 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol
  • Mono-O-acetateGanciclovir
  • Mono acetyl Ganciclovir
  • Mono-O-AcetylGanciclovir
  • Mono-O-acetateGanciclovir(Impuritycontrol)
  • Valganciclovir USP RC E
  • 2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl acetate
  • Ganciclovir Mono-O-acetate ISO 9001：2015 REACH
  • valganciclovirhydrochloride iMpurit E
  • Monacetyl ganciclor
  • Ganciclovir Impurity 30
  • Valganciclovir Related Compound E (Monoacetoxy Ganciclovir)
  • 2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydro...
  • 3-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-6,7-dihydroxy-3,5,6,7- tetrahydro-9H-imidazo[1,2-a]purin-9-one
  • O-Monoacetylganciclovir
  • Ganciclovir Impurity 16
  • 2(R,S)-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-3-acetoxy-1-propanol
  • Valganciclovir EP Impurity E
  • Valganciclovir Hydrochloride Impurity: 9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro-6H-Purin-6-one (Monoacetoxy ganciclovir)
  • 88110-89-8
  • Intermediates & Fine Chemicals
  • Pharmaceuticals