Ambicromil

Product Name
Ambicromil
CAS No.
58805-38-2
Chemical Name
Ambicromil
Synonyms
FPL-58668;Ambicromil;probicromil;ProbicromilCalcium;4,6-Dioxo-10-propyl-4H,6H-benzo[1,2-b:5,4-b']dipyran-2,8-dicarboxylic acid;4H,6H-Benzo[1,2-b:5,4-b']dipyran-2,8-dicarboxylic acid, 4,6-dioxo-10-propyl- (9CI)
CBNumber
CB91177991
Molecular Formula
C17H12O8
Formula Weight
344.274
MOL File
58805-38-2.mol
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Ambicromil Property

Melting point:
310-311 °C
Boiling point:
624.1±55.0 °C(Predicted)
Density 
1.604±0.06 g/cm3(Predicted)
pka
1.78±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0010665
Product name
AMBICROMIL
Purity
95.00%
Packaging
5MG
Price
$495.84
Updated
2021/12/16
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Ambicromil Chemical Properties,Usage,Production

Originator

Probicromil,ZYF Pharm Chemical

Uses

Anti-allergic (prophylactic).

Manufacturing Process

4,6-Dioxo-10-propyl-4H,6H-benzo[1,2-b:5,4-b']dipyran-2,8-carboxylic acid:
2 ml of benzyltrimethylammonium hydroxide was added to a solution of 18.3 g 2-propylresorcine and dimethyl acetylenedicboxylate in 500 ml of ethanol and the mixture obtained was heated for 20 hours at reflux. The solution was cooled, 30 g sodium hydroxide in 150 ml of water was added and all mass was heated for 2 hours at reflux. On cooling the reaction mixture was poured into 2 L of water and washed with ethyl acetate. The water layer was acidified with conc. hydrochloric acid and a precipitate fallen was collected, washed with water, and dried in vacuum at 80°C to give 21 g cream-colored solid product.
21 g above product was in portion added to 200 ml of chlorosulfonic acid by ice cooling. The temperature of reaction was not higher 10°C. Then the reaction mixture was heated for 2.5 hours at 50°C. On cooling it was poured into 3 L of ice/water, the fallen precipitate was filtered off, washed with water and dried in vacuum. The solid product was heated with 100 ml of ethanol, an insoluble part was collected and boiled with 100 ml of ethyl acetate. Insoluble product was centrifuged and dried in vacuum at 60°C. Yield of title product hydrate 10.5 g. 4,6-Dioxo-10-propyl-4H,6H-benzo[1,2-b:5,4-b']dipyran-2,8- carboxylic acid melted at 310°-311°C (deg).

Therapeutic Function

Antiallergic, Histamine H1 antagonist

Ambicromil Preparation Products And Raw materials

Raw materials

Preparation Products

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Ambicromil Suppliers

TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24131
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58