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Climazolam

Product Name
Climazolam
CAS No.
59467-77-5
Chemical Name
Climazolam
Synonyms
Climazolam;Ro-21-3982;8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine;4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-chlorophenyl)-1-methyl-
CBNumber
CB91178327
Molecular Formula
C18H13Cl2N3
Formula Weight
342.22
MOL File
59467-77-5.mol
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Climazolam Property

Boiling point:
522.7±60.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
pka
6.05±0.40(Predicted)
InChI
InChI=1S/C18H13Cl2N3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
InChIKey
CHCISLOJADQUNQ-UHFFFAOYSA-N
SMILES
N12C(C)=NC=C1CN=C(C1=CC=CC=C1Cl)C1=CC(Cl)=CC=C12
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0011078
Product name
CLIMAZOLAM
Purity
95.00%
Packaging
5MG
Price
$502.96
Updated
2021/12/16
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Climazolam Chemical Properties,Usage,Production

Description

Climazolam is a potent benzodiazepine which, following IV administration, has a very rapid onset of effect. It has a marketing authorization in Switzerland for use in dogs, but has been used in a wide variety of animals including cattle, sheep, horses and dogs (Rehm & Schatzmann, 1984). It is used as part of anaesthetic combinations. It is particularly effective for use with ketamine and, in horses, this combination has been used by constant rate infusion (CRI) to produce total intravenous anaesthesia (TIVA), the climazolam being reversed with sarmazenil (see below) at the end of surgery to produce a rapid recovery (BettschartWolfensberger et al., 1996). Climazolam (1.0–1.5 mg/kg) has also been used in combination with fentanyl (0.005–0.015 mg/kg) for anaesthesia in the dog (Erhardt et al., 1986).

Uses

Climazolam (Ro21-3982) was introduced under licence as a veterinary medicine by the Swiss Pharmaceutical company Gr?ub under the tradename Climasol. Climazolam is a benzodiazepine, specifically an imidazobenzodiazepine derivative developed by Hoffman-LaRoche. It is similar in structure to midazolam and diclazepam and is used in veterinary medicine for anesthetizing animals.

Indications

Climazolam: an injectable benzodiazepine approved in Europe for anesthesia in dogs and cats, for example, as premedication with an opioid or for induction with ketamine.
Climazolam is a possible alternative to midazolam, but its use will require a relaxing of the import regulations by Health Canada and of the minimum practice standards of the OMVQ (which encourages the use of approved drugs), since it is not approved in Canada.
If climazolam were approved in Canada (it is approved in Europe for dogs and cats), it could replace diazepam or midazolam in combination with ketamine or other induction agents.

Definition

Climazolam is an imidazobenzodiazepine derivative used in veterinary medicine as an anesthetic.

Overdosage

Dose (mg/kg): 0.5–2.0 IM, IV
Comments: In combination with an opioid or anaesthetic agent

Climazolam Preparation Products And Raw materials

Raw materials

Preparation Products

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Climazolam Suppliers

Anhui Ruihan Technology Co., Ltd
Tel
+8617756083858
Email
daisy@anhuiruihan.com
Country
China
ProdList
973
Advantage
58
Wuhan Han Sheng New Material Technology Co.,Ltd
Tel
+8617798174412
Email
admin01@hsnm.com.cn
Country
China
ProdList
2097
Advantage
58
Xiamen Wonderful Bio Technology Co., Ltd.
Tel
+8613043004613
Email
Sara@xmwonderfulbio.com
Country
China
ProdList
283
Advantage
58
GIHI CHEMICALS CO.,LIMITED
Tel
+8618058761490
Email
info@gihichemicals.com
Country
China
ProdList
49979
Advantage
58
Hebei Ningnan Trade Co. LTD
Tel
+86-18034019111
Email
admin@hbningnan.com
Country
China
ProdList
255
Advantage
58
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View Lastest Price from Climazolam manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.
Product
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 59467-77-5
Price
US $120.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
large quantity
Release date
2023-07-21
Anhui Ruihan Technology Co., Ltd
Product
Climazolam 59467-77-5
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000t/year
Release date
2023-09-11
Hebei Ningnan Trade Co. LTD
Product
Climazolam 59467-77-5
Price
US $100.00/KG
Min. Order
0.10000000149011612KG
Purity
99.99%
Supply Ability
20MT
Release date
2022-11-01

59467-77-5, ClimazolamRelated Search:


  • Climazolam
  • 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
  • Ro-21-3982
  • 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-chlorophenyl)-1-methyl-
  • 59467-77-5