6-bromo-2-fluoro-3-methoxybenzaldehyde
- Product Name
- 6-bromo-2-fluoro-3-methoxybenzaldehyde
- CAS No.
- 853792-27-5
- Chemical Name
- 6-bromo-2-fluoro-3-methoxybenzaldehyde
- Synonyms
- 6-bromo-2-fluoro-3-methoxybenzaldehyde;Benzaldehyde, 6-bromo-2-fluoro-3-methoxy-
- CBNumber
- CB91180445
- Molecular Formula
- C8H6BrFO2
- Formula Weight
- 233.03
- MOL File
- 853792-27-5.mol
6-bromo-2-fluoro-3-methoxybenzaldehyde Property
- Boiling point:
- 288.2±35.0 °C(Predicted)
- Density
- 1.601±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystalline powder
- color
- Off white to faint lemon
Safety
- WGK Germany
- 3
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- RNI00133
- Product name
- 6-Bromo-2-fluoro-3-methoxybenzaldehyde
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- B678730
- Product name
- 6-Bromo-2-fluoro-3-methoxybenzaldehyde
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- Z0893
- Product name
- 6-Bromo-2-fluoro-3-methoxybenzaldehyde
- Packaging
- 1g
- Price
- $157
- Updated
- 2021/12/16
- Product number
- Z0893
- Product name
- 6-Bromo-2-fluoro-3-methoxybenzaldehyde
- Packaging
- 5g
- Price
- $371
- Updated
- 2021/12/16
- Product number
- PC48737
- Product name
- 6-Bromo-2-fluoro-3-methoxybenzaldehyde
- Purity
- 98%
- Packaging
- 10g
- Price
- $464
- Updated
- 2021/12/16
6-bromo-2-fluoro-3-methoxybenzaldehyde Chemical Properties,Usage,Production
Synthesis
2357-52-0
68-12-2
853792-27-5
General procedure for the synthesis of 6-bromo-2-fluoro-3-methoxybenzaldehyde from 2-fluoro-4-bromoanisole and N,N-dimethylformamide: 1. n-Butyllithium/hexane solution (1.56 mol/L, 93.8 mL, 146 mmol) was slowly added to a tetrahydrofuran (THF, 10 mL) solution of diisopropylamine (22.2 mL, 159 mmol) under argon protection, keeping the reaction temperature at -78°C. 2. the mixture was warmed to 0 °C and stirred for 10 min, followed by cooling again to -78 °C. 3. a solution of 4-bromo-2-fluoroanisole (25.0 g, 122 mmol) in THF (10 mL) was added slowly and dropwise to the above LDA-THF solution. 4. After continuing to stir the reaction mixture at -78 °C for 30 min, N,N-dimethylformamide (DMF, 14.2 mL, 183 mmol) was added dropwise at the same temperature. 5. The reaction mixture was gradually brought to room temperature and stirred for 1 hour. 6. Upon completion of the reaction, the reaction was quenched by addition of saturated aqueous ammonium chloride solution to the mixture, followed by extraction with ethyl acetate. 7. The organic layers were combined, washed with saturated brine and dried over anhydrous magnesium sulfate. 8. The solvent was removed by depressurized concentration and the resulting solid was collected by filtration and washed with a solvent mixture of hexane/ethyl acetate (5:1) to afford the target product 6-bromo-2-fluoro-3-methoxybenzaldehyde (22.8 g, 80% yield) as colorless crystals. Product characterization data: 1H NMR (CDCl3, δ): 3.91 (s, 3H), 7.04 (t, J = 8.7 Hz, 1H), 7.39 (dd, J = 1.8, 8.7 Hz, 1H), 10.32 (d, J = 1.0 Hz, 1H).
References
[1] Patent: EP1726584, 2006, A1. Location in patent: Page/Page column 28
[2] Patent: US2016/207916, 2016, A1. Location in patent: Paragraph 0047; 0052-0053
[3] Patent: WO2011/94450, 2011, A1. Location in patent: Page/Page column 149
[4] Patent: US2015/291629, 2015, A1. Location in patent: Paragraph 1139
6-bromo-2-fluoro-3-methoxybenzaldehyde Preparation Products And Raw materials
Raw materials
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View Lastest Price from 6-bromo-2-fluoro-3-methoxybenzaldehyde manufacturers
- Product
- 6-bromo-2-fluoro-3-methoxybenzaldehyde 853792-27-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-10-28