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thioperamide maleate salt

Product Name
thioperamide maleate salt
CAS No.
148440-81-7
Chemical Name
thioperamide maleate salt
Synonyms
MR-12842 maleate;Thioperamide maleate, H3 antagonist;N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1);MR-12842,inhibit,Thioperamide maleate,MR 12842,MR12842,Histamine Receptor,Inhibitor,Thioperamide
CBNumber
CB91216162
Molecular Formula
C15H24N4SC4H4O4
Formula Weight
0
MOL File
148440-81-7.mol
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thioperamide maleate salt Property

storage temp. 
desiccated under inert gas
solubility 
H2O: >10mg/mL
form 
solid
color 
white
Water Solubility 
H2O: >10mg/mL
DMSO: 12mg/mL
ethanol: 3mg/mL
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T123
Product name
Thioperamide maleate salt
Purity
solid
Packaging
10mg
Price
$93.8
Updated
2025/07/31
Sigma-Aldrich
Product number
T123
Product name
Thioperamide maleate salt
Purity
solid
Packaging
25mg
Price
$225.4
Updated
2025/07/31
Cayman Chemical
Product number
10011127
Product name
Thioperamide (maleate)
Purity
≥98%
Packaging
1mg
Price
$15
Updated
2024/03/01
Cayman Chemical
Product number
10011127
Product name
Thioperamide (maleate)
Purity
≥98%
Packaging
5mg
Price
$57
Updated
2024/03/01
Sigma-Aldrich
Product number
T123
Product name
Thioperamide maleate salt
Purity
solid
Packaging
100mg
Price
$977
Updated
2025/07/31
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thioperamide maleate salt Chemical Properties,Usage,Production

Description

Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg. At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.

Uses

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

Biochem/physiol Actions

Thioperamide is a potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.

in vivo

Thioperamide (5-20 mg/kg; i.p.) is able to facilitate reconsolidation of a contextually-conditioned fear memory in C57BL/6J mice[4].

Animal Model:Naive female C57BL/6J mice[4]
Dosage:5, 10 or 20 mg/kg
Administration:Injections (i.p.)
Result:Facilitated reconsolidation of a contextually-conditioned fear memory.

IC 50

H3 Receptor

References

[1] GALINA MEIER . Influence of imidazole replacement in different structural classes of histamine H3-receptor antagonists[J]. European Journal of Pharmaceutical Sciences, 2001, 13 3: Pages 249-259. DOI: 10.1016/s0928-0987(01)00106-3
[2] CHIE HARADA. Inhibitory effect of iodophenpropit, a selective histamine H3 antagonist, on amygdaloid kindled seizures[J]. Brain Research Bulletin, 2004, 63 2: Pages 143-146. DOI: 10.1016/j.brainresbull.2004.02.001

thioperamide maleate salt Preparation Products And Raw materials

Raw materials

Preparation Products

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thioperamide maleate salt Suppliers

China 26 Switzerland 1 United States 7 Global 34
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  • N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt
  • 1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1)
  • MR-12842 maleate
  • MR-12842,inhibit,Thioperamide maleate,MR 12842,MR12842,Histamine Receptor,Inhibitor,Thioperamide
  • Thioperamide maleate, H3 antagonist
  • 148440-81-7