BIIE 0246
- Product Name
- BIIE 0246
- CAS No.
- 246146-55-4
- Chemical Name
- BIIE 0246
- Synonyms
- BIIE 0246;AR-H 053591;BIIE-0246;BIIE0246;N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-;(2S)-5-(diaminomethylideneamino)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-2-[[2-[1-[2-oxo-2-[4-(6-oxo-5,11-dihydrobenzo[c][1]benzazepin-11-yl)piperazin-1-yl]ethyl]cyclopentyl]acetyl]amino]pentanamide;N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide;Cyclopentaneacetamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-
- CBNumber
- CB9122491
- Molecular Formula
- C49H57N11O6
- Formula Weight
- 896.05
- MOL File
- 246146-55-4.mol
BIIE 0246 Property
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- <67.2mg/ml in DMSO; <23.55mg/ml in ethanol
- form
- solid
- pka
- 13.28±0.40(Predicted)
- color
- White
N-Bromosuccinimide Price
- Product number
- B384503
- Product name
- BIIE0246
- Packaging
- 0.5mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CS-0022426
- Product name
- BIIE-0246
- Purity
- >99.0%
- Packaging
- 1mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- B6836
- Product name
- BIIE0246
- Packaging
- 1mg
- Price
- $251
- Updated
- 2021/12/16
- Product number
- BIO0000364
- Product name
- BIIE-0246
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.84
- Updated
- 2021/12/16
BIIE 0246 Chemical Properties,Usage,Production
Uses
BIIE 0246, is a selective non-peptide antagonist which binds to the neuropeptide NPY2-R in a competitive manner. Studies have also shown that BIIE 0246 is highly lipophilic and as a result BIIE 0246 builds up at membranes near the receptors.
Biological Activity
Potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y 2 receptor (IC 50 = 15 nM). Displays > 650-fold selectivity over Y 1 , Y 4 and Y 5 receptors. Active in vivo .
References
[1]. doods h, gaida w, wieland ha, et al. biie0246: a selective and high affinity neuropeptide y y(2) receptor antagonist. eur j pharmacol, 1999, 384(2-3): r3-5.
[2]. el bahh b, cao jq, beck-sickinger ag, et al. blockade of neuropeptide y(2) receptors and suppression of npy's anti-epileptic actions in the rat hippocampal slice by biie0246. br j pharmacol, 2002, 136(4): 502-509.
[3]. dumont y, cadieux a, doods h, et al. biie0246, a potent and highly selective non-peptide neuropeptide y y(2) receptor antagonist. br j pharmacol, 2000, 129(6): 1075-1088.
[4]. abbott cr, small cj, kennedy ar, et al. blockade of the neuropeptide y y2 receptor with the specific antagonist biie0246 attenuates the effect of endogenous and exogenous peptide yy(3-36) on food intake. brain res, 2005, 1043(1-2): 139-144.
[5]. bacchi f, mathé aa, jiménez p, et al. anxiolytic-like effect of the selective neuropeptide y y2 receptor antagonist biie0246 in the elevated plus-maze. peptides, 2006, 27(12): 3202-3207.